Compositions and methods for treating insulin resistance and diabetes mellitus

A technology for insulin resistance and diabetes, used in drug combinations, anti-inflammatory agents, metabolic diseases, etc., to solve problems such as retention and weight gain

Inactive Publication Date: 2012-04-11
REVALESIO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the treatments available today have considerable side effects such as abdominal...

Method used

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  • Compositions and methods for treating insulin resistance and diabetes mellitus
  • Compositions and methods for treating insulin resistance and diabetes mellitus
  • Compositions and methods for treating insulin resistance and diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0343] refer to Figure 12 , depicts a mixing device 5000. Mixing device 5000 is an alternative embodiment of mixing device 100 . The same reference numerals are used herein to identify components of the mixing device 5000 that correspond substantially similarly to components of the mixing device 100 . Only components of the mixing device 5000 that are different from those of the mixing device 100 will be described.

[0344] The mixing device 5000 includes a housing 5500 for accommodating a rotor 600 and a stator 5700 . The stator 5700 may be non-rotatably connected to the housing 5500 by its first end 5712 and its second end 5714 . A chamber 5800 is defined between housing 5500 and a portion 5820 of stator 5700 flanked by first end 5712 and second end 5714 . Housing 5500 includes an input port 5830 that provides access to chamber 5800 . The input port 5830 may be oriented substantially perpendicular to the rotational axis "α". However, this is not required.

[0345] Th...

Embodiment 1

[0508] Dissolved Oxygen Stability

[0509] Such as Figure 30 As shown in , the dissolved oxygen levels are shown in each capped 500ml thin-walled plastic bottle and 1000ml glass bottle stored at 65 degrees Fahrenheit.

[0510] It can be seen that when the plastic bottle was opened about 65 days after bottling, the dissolved oxygen level in the water was about 27.5 ppm. When the second bottle was opened about 95 days after bottling, the dissolved oxygen level was about 25 ppm. Likewise, for the glass bottles, the dissolved oxygen level was about 40 ppm at day 65 and about 41 ppm at day 95. Thus, the graph shows that when using the described system and method to diffuse oxygen into the fluid, the dissolved oxygen levels in both plastic and glass bottles remain relatively high at 65 degrees Fahrenheit.

Embodiment 2

[0512] Decayed Oxygen Content in Balanced Salt Solution

[0513] Figure 33 Shown is the dissolved oxygen retention for 500 ml of balanced salt solution initially having a dissolved oxygen level of 5 ppm. After enriching the solution with the diffuser of the present invention, the dissolved oxygen level was about 41 ppm at standard temperature and pressure. Keep the solution in an amber glass bottle. After 1 hour, the dissolved oxygen level was 40 ppm; after 2 hours it was 36 ppm; after 3 hours it was 34 ppm; after about 4.5 hours it was just over 30 ppm. The final measurement was made just before 6 hours, at which time the dissolved oxygen level was about 28 ppm.

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Abstract

Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating diabetes and diabetes-associated conditions or disorders (e.g., insulin resistance), or symptoms thereof. Provided are electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

Description

field of invention [0001] Certain embodiments disclosed herein relate to treating an insulin resistant and / or diabetic condition or disorder, or at least one thereof, in a subject by administering a therapeutic composition comprising at least one electrokinetically altered fluid as disclosed herein symptom. Certain embodiments disclosed herein relate to the regulation of cellular membranes, membrane potential, membrane proteins (such as membrane receptors, including but not limited to G-protein coupled receptors), and intercellular junctions (such as tight junctions, gap junctions, zona adherens, and At least one of the desmasomes) regulates or modulates intracellular signal transduction. Certain aspects relate to electrokinetically altered fluids (gas-enriched electrokinetic fluids) comprising charge-stabilized oxygen-containing nanostructured ionic aqueous solutions in an amount sufficient to provide modulation of at least one of cell membrane potential and cell membrane co...

Claims

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Application Information

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IPC IPC(8): A61K9/14
CPCA61K9/0014A61K9/08A61K47/02A61K9/0009A61K45/06A61K31/58A61K33/00A61P27/02A61P29/00A61P43/00A61P9/10A61P3/10A61K2300/00
Inventor 理查德·L·华森安东尼·B·伍德格雷戈里·J·阿咸宾
Owner REVALESIO CORP
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