Enrofloxacin long-acting injection and preparation method thereof

A technology of enrofloxacin and injection, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of large animal stress response, low content of injection, and the need for more To avoid problems such as one-time administration, to achieve the effect of less irritation, high content, and reduced administration volume

Active Publication Date: 2013-05-01
石家庄市丰强动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of enrofloxacin long-acting injection and preparation method thereof, can overcome the current enrofloxacin injection due to the low content of the injection and the high pH value of the animal caused by the large stress response, need Multiple dosing issues, etc.

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  • Enrofloxacin long-acting injection and preparation method thereof
  • Enrofloxacin long-acting injection and preparation method thereof
  • Enrofloxacin long-acting injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Enrofloxacin long-acting injection, the ingredients per 100ml are as follows: Enrofloxacin 20g, lactic acid 5ml, sodium metabisulfite 0.1g, propylene glycol 10ml, EDTA-2Na0.02g, hydroxymethylcellulose 5g, benzyl alcohol 1ml, an appropriate amount of pH regulator, and the rest water for injection.

[0028] The preparation method is as follows: first add lactic acid to 30mL water and mix evenly, then add enrofloxacin and stir to dissolve for later use. Dissolve sodium metabisulfite and EDTA-2Na with 20 mL of water for injection, then add propylene glycol, and finally add hydroxymethylcellulose to dissolve it. Slowly add the solution containing hydroxymethylcellulose into the solution in which enrofloxacin is dissolved, stir to make it evenly mixed, add benzyl alcohol, adjust the pH to about 4.5 with sodium hydroxide solution, and finally add water for injection to dilute to 100mL. The prepared solution is filtered through a microporous membrane, packaged, and sterilized...

Embodiment 2

[0030] Enrofloxacin long-acting injection, the ingredients per 100ml are as follows: Enrofloxacin 10g, methanesulfonic acid 3ml, sodium bisulfite 0.2g, polyethylene glycol 15ml, EDTA-2Na0.01g, methylcellulose 3g , 0.5ml of phenol, an appropriate amount of pH regulator, and the balance is water for injection.

[0031] The preparation method is as follows: first add methanesulfonic acid to 40mL water and mix evenly, then add enrofloxacin and stir to dissolve for later use. Dissolve sodium bisulfite and EDTA-2Na with 20 mL of water for injection, then add polyethylene glycol, and finally add methylcellulose to dissolve it. Finally, slowly add the solution containing methylcellulose into the solution in which enrofloxacin is dissolved, stir to make it evenly mixed, and then add the preservative phenol. Adjust the pH to about 4.5 with lactic acid. Finally add water for injection to make up to 100mL. The prepared solution is filtered through a microporous membrane and then packag...

Embodiment 3

[0033] Enrofloxacin long-acting injection, the ingredients per 100ml are as follows: 20g of enrofloxacin, 3ml of lactic acid, 0.1g of sodium metabisulfite, 15ml of N-methylpyrrolidone, 0.2g of citric acid, 5g of polyvinylpyrrolidone, 0.5ml of phenylethyl alcohol, an appropriate amount of pH regulator, and the balance is water for injection.

[0034] The preparation method is as follows: first add lactic acid to 30mL water and mix evenly, then add enrofloxacin and stir to dissolve for later use. Dissolve sodium metabisulfite and citric acid with 20 mL of water for injection, then add N-methylpyrrolidone, and finally add polyvinylpyrrolidone to dissolve it. Finally, slowly add the solution containing polyvinylpyrrolidone into the solution in which enrofloxacin is dissolved, stir to make it evenly mixed, and add phenethyl alcohol. Adjust the pH to about 5.0 with lactic acid. Finally add water for injection to make up to 100mL. The prepared solution is filtered through a microp...

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Abstract

The invention especially relates to high-content weak acidic enrofloxacin long-acting injection for livestock and a preparation method thereof, belonging to the field of veterinary drugs. Each 100 ml of the injection comprises 10 to 20 g of enrofloxacin, 3 to 5 ml of a cosolvent, 0.01 to 0.5 g of a complexing agent, 3 to 10 g of a high-molecular slow release material, 0.05 to 1 ml of an antiseptic, 10 to 30 ml of an organic solvent and 0.1 to 0.2 g of an anti-oxidant, with the balance being injection water, and the pH value of the injection is 4 to 7. The invention provides veterinary clinical practice with the high-content weak acidic enrofloxacin long-acting injection and the preparation method thereof; the injection has the advantages of high content of enrofloxacin, small irritation, good stability and a long-acting effect; the preparation method is simple and is convenient for large scale production.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to a long-acting injection of high-content weakly acidic enrofloxacin for veterinary use and a preparation method thereof. Background technique [0002] Enrofloxacin is the world's first animal-specific quinolone antibiotic. Because of its unique mechanism of action, it can kill most pathogenic bacteria and is a broad-spectrum bactericidal antibacterial drug. It has a good killing effect on common pathogenic bacteria such as Escherichia coli, Salmonella, Haemophilus, Pasteurella, Staphylococcus aureus, Mycoplasma, Chlamydia, etc., especially has special effects on Mycoplasma. It still has a strong killing effect on mycoplasma resistant to tylosin and tiamulin. The minimum inhibitory concentration (Minimal inhibitory concentrations, MIC) value for most pathogens is low, and it plays an important role in the prevention and treatment of bacterial diseases and mycoplasma infections. En...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/38A61K47/32A61K47/34A61P31/04
Inventor 陈鹏举吴华王汝都柴建亭赵庆枫李向超袁水霞胡梅陈黎明张国辉
Owner 石家庄市丰强动物药业有限公司
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