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A medicinal cream made using framycetin sulphate cream and chitosan, and a process to make it

A technology of neomycin sulfate and cream, which is used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2012-04-25
苏鲁・苏布拉马尼・瓦南加穆迪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] - The incorporation of bioactive polymers (also known as biopolymers) is a complex process in which formulation excipients or process parameters for correct biopolymers or natural interactions are not adequately considered at the drug design stage and optimized to To enhance and complement therapeutic outcomes, formulation stability can be compromised

Method used

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  • A medicinal cream made using framycetin sulphate cream and chitosan, and a process to make it
  • A medicinal cream made using framycetin sulphate cream and chitosan, and a process to make it
  • A medicinal cream made using framycetin sulphate cream and chitosan, and a process to make it

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0131] A novel dermatological cream for the topical treatment of bacterial skin infections and associated wound healing, wherein the cream comprises neomycin sulfate B and a biopolymer provided in a cream base comprising at least one of preservatives, primary and secondary emulsifiers, waxy materials, co-solvents, acids and water, preferably purified water.

[0132] Embodiment 1

[0133] The novel cream for skin disclosed in preferred embodiment 1, wherein the cream further includes: any one of the group including buffering agent, antioxidant, chelating agent, humectant or any combination thereof.

Embodiment approach 2

[0135] Novel cream for skin as disclosed in preferred embodiment 1, wherein

[0136] - said neomycin B sulfate agent is added in an amount of about 0.5% w / w to about 15% w / w, preferably 0.5 to 5.0% w / w and more preferably about 1.0% w / w; and

[0137] - the biopolymer is in the form of chitosan, in an amount of about 0.01% to about 1% w / w, preferably about 0.01% w / w to about 0.5% w / w, and most preferably about 0.25% w / w In addition, the functional excipient of chitosan is classified as USP conformant and is selected from any grade such as long chain, medium chain and short chain, and has a molecular weight ranging from 50 kDa to 5000 kDa,

[0138]- said primary and secondary emulsifiers are selected from the group comprising cetearyl alcohol, cetearyl alcohol-1000, cetyl alcohol, stearyl alcohol, polysorbate-80, Span-80, etc. The amount of 1% (w / w) to 20% (w / w) is added; the waxy material is selected from the group comprising white soft paraffin, liquid paraffin, hard paraffin...

Embodiment approach 3

[0140] The novel cream disclosed in preferred embodiment 1 and embodiment 2 further includes a buffer selected from the group comprising disodium hydrogen orthophosphate, sodium hydrogen orthophosphate, calcium lactate, etc. or any combination thereof and Added in an amount of 0.05% (w / w) to 1.00% (w / w).

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Abstract

The present invention is directed to a composition for treating bacterial skin infections, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) an active pharmaceutical ingredient (API) composition in the form of framycetin sulphate used in treating bacterial skin infections, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, and an anti bacterial agent in the form of framycetin sulphate, are incorporated in cream base for use in treating bacterial skin infections with allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.

Description

technical field [0001] The present invention relates to compositions for the treatment of bacterial skin infections and skin regeneration. More specifically, the present invention relates to a medicinal cream comprising a biopolymer and an antibacterial active ingredient, neomycin B sulfate. Background technique [0002] Skin diseases are broadly classified by the bacterial form or fungus from which they arise. Antifungal or antibacterial compositions are commonly used as lotions, creams or ointments. Also, in some cases it is difficult to determine whether the skin condition is due to a bacterial factor or a fungus. [0003] One approach to treating skin diseases is eradication by trial and error. The antibacterial or antifungal composition is administered alternately to monitor response and modify treatment. The main disadvantage of this method is that multiple sessions per day are required during the treatment period. This is inconvenient and uneconomical for most pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/107A61K31/7036A61K47/36
CPCA61K31/7036A61K9/0014A61K9/06A61K47/36A61K31/70A61P17/00A61P17/02A61P31/04A61P43/00
Inventor 苏鲁·苏布拉马尼·瓦南加穆迪马达范·斯里尼瓦桑尼拉坎丹·纳拉亚南·许利耶尔库普萨米·森蒂库马尔
Owner 苏鲁・苏布拉马尼・瓦南加穆迪
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