Radioactive medicine synthesis module capable of being repeatedly used in same day
A radiopharmaceutical and radioactive technology, applied in the field of radiopharmaceutical synthesis modules, can solve the problem that the use cycle is affected by the half-life of the nuclide and can only be used once, and achieves the effect of easy control and simple operation.
Active Publication Date: 2013-02-13
NANJING PET TRACER
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Problems solved by technology
[0006] The purpose of the present invention is to solve the shortcomings of the existing radiopharmaceutical synthesis module that can only be used once a day, and its service cycle is affected by the half-life of the nuclide, and provide a synthesis module that can be used multiple times a day for radiopharmaceuticals with long and short half-lives.
Method used
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Effect test
Embodiment 18
[0026] Example 18 Synthesis of F-FDG (fluorodeoxyglucose)
[0027] First add water, anhydrous acetonitrile and mannose trifluoride solution in reagent bottles 30, 31 and 32 respectively, add water and 0.5mol / L sodium hydroxide solution in purification reagent bottles 20 and 21 respectively, and various medicinal liquids The addition of is through the pressure of the compressed nitrogen in the cylinder to press it into the synthesis module. The cleaning method of the synthesis module: first press the water in the reagent bottle 30 into the reaction device 12 to clean it, and then press the anhydrous acetonitrile in the reagent bottle 31 into the reaction device 12 to clean it.
[0028] After cleaning, a certain amount of K containing 18F is then passed through meter 11 222 / K 2 CO 3 The aqueous solution is added to the reaction device 12, the heating device 13 is turned on, the temperature is heated to 116°C, the water in the solution is evaporated, and the steam is discharg...
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The invention provides a radioactive medicine synthesis module capable of being repeatedly used in the same day, which is characterized by comprising a reaction device, a purification device, a radiation protection cover, a plurality of reagent bottles and a plurality of purification reagent bottles, wherein the reaction device and the purification device are arranged in the radiation protection cover; the reagent bottles and the purification reagent bottles are arranged outside the radiation protection cover; a nonradioactive raw material enters the reaction device through pipelines and valves which are connected with the reagent bottles; a radioactive raw material enters the reaction device through another pipeline; the outlet of the reaction device is connected with the inlet of the purification device through a pipeline and a valve; and the inlet of the purification device is connected with the purification reagent bottles through pipelines and valves. Various reagents can be put, a product can be purified and the device can be washed at any time under the condition that the radiation protection cover of the synthesis module is not opened, and the aim of synthesizing different radioactive medicines by repeatedly using the module in the same day is fulfilled. The synthesis module is easy to operate and control.
Description
technical field [0001] The invention belongs to the field of radiopharmaceutical synthesis, and in particular relates to a radiopharmaceutical synthesis module that can be used multiple times a day. Background technique [0002] With the rapid development of genomics, proteomics and disease genomics, the diagnosis of diseases is developing from traditional characterization observation and routine biochemical experiment detection to the recognition of microscopic features at the gene and molecular levels. Imaging technology can deeply understand the occurrence and development process of diseases from the level of genes and proteins, and can realize an overall, continuous, non-invasive specific detection method that cannot be replaced by existing microscopic analysis. The theory and technology of biomolecular imaging in vivo will help to provide new means of prevention, diagnosis and treatment. Radiopharmaceuticals or radiolabeled molecular probes are the basis and prerequisi...
Claims
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IPC IPC(8): A61K51/00
Inventor 郭先伟李新平虞善友王燕颜成龙
Owner NANJING PET TRACER