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Preparation method for surface enhanced Raman scattering substrate based on cationic resin

A surface-enhanced Raman and cationic resin technology, which is applied in the field of biochemical analysis and detection, and laser Raman spectroscopy detection, can solve the problems of difficult control of substrate uniformity, complex preparation process, pollution, etc., and achieve easy control of the production process and enhanced effect Obvious, good signal reproducibility effect

Inactive Publication Date: 2013-06-19
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation process of this method is relatively complicated, the uniformity of the substrate is not easy to control, and the introduction of organic reagents in the preparation process is easy to cause pollution to the environment

Method used

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  • Preparation method for surface enhanced Raman scattering substrate based on cationic resin
  • Preparation method for surface enhanced Raman scattering substrate based on cationic resin
  • Preparation method for surface enhanced Raman scattering substrate based on cationic resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Add 2g of silver nitrate to 30mL of pure water, and stir to dissolve it completely;

[0043] (2) take by weighing 5g cationic resin and join in the silver nitrate solution that step (1) obtains, stir 2 hours with the rotating speed of 200rpm;

[0044] (3) filter the solution obtained in step (2), and wash the filtered cationic resin with pure water 5 times;

[0045] (4) add 20mL pure water to the resin after the cleaning of step (3) gained and be placed in 10 ℃ of water baths, stir with the rotating speed of 200rpm; Add the sodium borohydride solution 6mL that mass percent concentration is 10% then, continue with the same Stir at a rotating speed, react for 30 seconds, and the surface of the resin is covered with a layer of nano-silver particles; figure 1 shown in the figure on the right.

[0046] (5) Wash the silver-coated resin obtained in step (4) several times, and dry it in a constant temperature oven to obtain a surface-enhanced Raman scattering substrate wi...

Embodiment 2

[0049] (1) Add 1.5g of silver nitrate to 30mL of pure water and stir to dissolve it completely;

[0050] (2) Take by weighing 4g cationic resin and join in the silver nitrate solution that step (1) obtains, stir about 2 hours with the rotating speed of 200rpm;

[0051] (3) filter the solution obtained in step (2), and wash the filtered cationic resin with pure water 5 times;

[0052] (4) add 20mL pure water to the resin after step (3) gained cleaning and place in 10 ℃ of water baths, stir with the rotating speed of 200rpm; Then add the sodium borohydride solution 6mL that the mass percent concentration is 10%, continue with the same Stir at high speed, react for 30 seconds, and the surface of the resin is covered with a layer of nano-silver particles;

[0053] (5) Wash the silver-coated resin obtained in step (4) several times, and dry it in a constant temperature oven to obtain a surface-enhanced Raman scattering substrate with stable detection signals.

[0054] Dissolve p-...

Embodiment 3

[0057] (1) Add 3g of silver nitrate to 50mL of pure water and stir to dissolve it completely;

[0058] (2) Take 8g cationic resin and join in the silver nitrate solution that step (1) obtains, stir about 2 hours with the rotating speed of 200rpm;

[0059] (3) filter the solution obtained in step (2), and wash the filtered cationic resin with pure water for 4 times;

[0060] (4) add 20mL pure water to the resin after step (3) gained cleaning and be placed in 10 ℃ of water baths, stir with the rotating speed of 200rpm; Add the sodium borohydride solution 8mL that mass percent concentration is 10% then, continue with the same Stir at high speed, react for 40 seconds, and the surface of the resin is covered with a layer of nano-silver particles;

[0061] (5) Wash the silver-coated resin obtained in step (4) several times, and dry it in a constant temperature oven to obtain a surface-enhanced Raman scattering substrate with stable detection signals.

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Abstract

The invention discloses a preparation method for a surface enhanced Raman scattering substrate based on a cationic resin. The method comprises the following steps: completely dissolving silver nitrate in pure water; adding the cationic resin for an ion exchange reaction; rinsing the cationic resin with pure water after the reaction, adding a proper amount of pure water, placing the resin in ice bath, adding a hydroboron solution for a reduction reaction and cleaning and drying the resin to obtain the surface enhanced Raman scattering substrate whose surface is coated with silver. The substrate prepared by using the method has good spectral signal stability and repeatability and long preservation time; the preparation method is simple, costs little and can be used for detection and analysis of low content compounds.

Description

technical field [0001] The invention relates to a preparation method of a novel surface-enhanced Raman scattering substrate, which belongs to the technical field of laser Raman spectrum detection and the field of biochemical analysis and detection. Background technique [0002] Traditional laser Raman technology tends to have weak signals, especially when the concentration of the analyte is low, conventional Raman technology is unable to do what it wants, and enhancement and other means are needed. In the mid-1970s, Fleischmann, van Duyne, Creighton et al. found that the rough silver electrode surface can enhance the Raman signal, and can obtain an amplified Raman signal when detecting pyridine. This technique is called surface-enhanced Raman scattering. Surface Enhanced Raman Scattering (SERS) has attracted widespread attention since its discovery due to its low detection limit, highly enhanced vibrational signal, and good selectivity and sensitivity. When molecules with r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65B22F9/24B82Y40/00
Inventor 占金华倪寿清姜玮朱晨
Owner SHANDONG UNIV
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