Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of compound pseudoephedrine hydrochloride capsule

An aminomamin capsule and capsule technology, which can be used in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as impacts that have not yet been reported

Active Publication Date: 2012-05-16
SINOVA LABS +1
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there have been quite a lot of researches on the harm of chloroacetic acid to the human body, but the impact of residual chloroacetic acid in sodium starch glycolate on drugs has not yet been reported.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of compound pseudoephedrine hydrochloride capsule
  • Preparation method of compound pseudoephedrine hydrochloride capsule
  • Preparation method of compound pseudoephedrine hydrochloride capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Huzhou Outlook 20100129

Embodiment 2

[0030] Example 2 Huzhou Outlook 20100360

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a compound pseudoephedrine hydrochloride capsule. The preparation method provided by the invention is characterized by comprising the following steps of detecting chloroacetic acid content of sodium carboxymethyl starch, when the weight of chloroacetic acid is 0 to 0.05% of that of sodium carboxymethyl starch, mixing active ingredients and auxiliary materials well, carrying out granulation, drying, sieving and loading to obtain the compound pseudoephedrine hydrochloride capsule. Through the preparation method provided by the invention, it is avoided that chlorphenamine maleate and chloroacetic acid of the compound pseudoephedrine hydrochloride capsule undergo a chemical reaction in storage to produce an impurity shown in the formula I and thus chlorphenamine maleate content is reduced. The preparation method provided by the invention reduces factors causing preparation destabilization and improves preparation safety.

Description

technical field [0001] The invention relates to a preparation method of Ammamimin capsules, in particular to a method for controlling the content of chloroacetic acid in sodium carboxymethyl starch and a detection method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Ammamimin Capsules (Rilida) is a compound over-the-counter medicine for colds produced by Shenzhen Zhonglian Pharmaceutical Co., Ltd. Its main active ingredients are acetaminophen, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate. Among them, acetaminophen can inhibit the synthesis of prostaglandins, and has antipyretic and analgesic effects; pseudoephedrine hydrochloride can selectively constrict blood vessels in the upper respiratory tract, eliminate nasal congestion, and relieve symptoms such as nasal congestion, runny nose, and sneezing; dextromethorphan hydrobromide It can inhibit the cough center and produce ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/167A61K31/137A61K31/4402A61K9/48A61P31/16A61P29/00A61P11/02A61P11/14A61P37/08G01N30/02
Inventor 李嘉和张群艳杨镜刘军梁永军
Owner SINOVA LABS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products