Method for transdermal iontophoretic delivery of chelated agents

Abstract

Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products.; The complex is then dissociated to release the iron where it may be bound by transferrin or ferritin for storage or metabolic use such as heme synthesis.

Description

field of invention [0001] Embodiments described herein relate to the transdermal delivery of various therapeutic agents. More specifically, embodiments described herein relate to transdermal iontophoretic delivery of various chelation complexes. More specifically, embodiments described herein relate to transdermal iontophoretic delivery of various iron chelating complexes. Background technique [0002] Nutrient deficiency is a global health problem. In particular, iron deficiency is the most common form of nutritional deficiency worldwide, affecting more than 3 billion people in third world countries alone. It is associated with a variety of diseases and conditions and is responsible for 100,000 maternal deaths during childbirth and 134,000 child deaths each year. It is also concurrent with multiple parasitic infections and is a key underlying factor in impaired psychological development in children. [0003] Iron deficiency anemia is one of the more serious conditions c...

AI Technical Summary

Problems solved by technology

The latter can be particularly problematic in third world countries where sufficient refrigeration and sterile needles are not readily available, limiting shelf life and exposing patients to infection

In addition, IV administration may contain several risk factors, including anaphylaxis and cardiovascular complications

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