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Deformed polymer tube and completely biodegradable polymer stent prepared by same

A polymer tube and deformation technology, which is applied in the field of preparation of medical implant stents, can solve the problems of uniform wall thickness and shape stability of difficult tubes, and achieve delayed physical aging time, good radial strength, and simple preparation methods Effect

Active Publication Date: 2012-06-20
SHENZHEN SALUBRIS BIOMEDICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The deformed polymer pipe reported in the published literature so far adopts the internal stamping method to make it difficult to maintain the uniform wall thickness and shape stability of the pipe after expansion, and the uniform wall thickness and shape are the most important properties of the deformed pipe. one of the influencing factors

Method used

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  • Deformed polymer tube and completely biodegradable polymer stent prepared by same
  • Deformed polymer tube and completely biodegradable polymer stent prepared by same
  • Deformed polymer tube and completely biodegradable polymer stent prepared by same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] refer to image 3 , Figure 4 and Figure 5 , polymer pipe 201 (L-PLA, molecular weight is 40W~50W, the weight percentage ratio of L-PLA type polylactic acid monomer is 80%, crystallinity is 15%, pipe inner diameter is 0.50mm, wall thickness 1.50 mm) is placed in the heat transfer mold 102, the heating mold 101 moves axially at a speed of 0.5mm / s, the preheating temperature is 85°C, and the preheating is performed for 30 seconds; after the preheating is completed, keep the preheating temperature unchanged, and the mechanical core The shaft 103 precesses at a forward speed of 0.5 mm / s and a rotational speed of 10 degrees / s, and controls the size of the polymer pipe 201 through the outer diameter of the mechanical mandrel 103 and the inner diameter of the heat transfer mold 102, so that the radial expansion rate RE is 550%; while the mechanical mandrel 103 is screwing in, the polymer pipe 201 is axially stretched at a speed of 0.5mm / sec, so that the axial stretch rate A...

Embodiment 2

[0052] refer to image 3 , Figure 4 and Figure 5 , the polymer pipe 201 (L-PLA, molecular weight is 30W~40W, the weight percentage ratio of L-PLA type polylactic acid monomer is 90%, crystallinity is 20%, pipe inner diameter is 0.5mm, wall thickness 0.1 mm) is placed in the heat transfer mold 102, the heating mold 101 moves axially at a speed of 1mm / s, the preheating temperature is 80°C, and the preheating is for 20 seconds; after the preheating is completed, keep the preheating temperature unchanged, and the mechanical core The shaft 103 precesses at a forward speed of 1 mm / s and a rotational speed of 10 degrees / s, and controls the size of the polymer pipe 201 through the outer diameter of the mechanical mandrel 103 and the inner diameter of the heat transfer mold 102, so that the radial expansion rate RE is 600 %; while the mechanical mandrel 103 is screwing in, stretch the polymer pipe 201 axially at a speed of 1.5mm / sec, so that the axial stretch rate AE is 300%; after...

Embodiment 3

[0054] refer to image 3 , Figure 4 and Figure 5 , polymer pipe 201 (L-PLA, molecular weight is 40W~50W, the weight percentage ratio of L-PLA type polylactic acid monomer is 90%, crystallinity is 5%, pipe inner diameter is 0.55mm, wall thickness 2mm ) is placed in the heat transfer mold 102, the heating mold 101 moves axially at a speed of 0.2mm / s, the preheating temperature is 90°C, and the preheating mold is 30 seconds; after the preheating is completed, keep the preheating temperature unchanged, and the mechanical core The shaft 103 precesses at a forward speed of 0.2 mm / s and a rotational speed of 10 degrees / s, and controls the size of the polymer pipe 201 through the outer diameter of the mechanical mandrel 103 and the inner diameter of the heat transfer mold 102, so that the radial expansion rate RE is 580%; while the mechanical mandrel 103 is screwing in, the polymer pipe 201 is axially stretched at a speed of 1.0mm / sec, so that the axial stretch rate AE is 270%; af...

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Abstract

The invention provides a deformed polymer tube, which mainly consists of L-PLA type polylactic acid (L-poly- lactic acid) with the molecular weight ranging from 5W to 50W. The weight percentage of each L-PLA type polylactic acid monomer ranges from 80% to 95%, the crystallinity of each L-PLA type polylactic acid monomer ranges from 30% to 60%, the inner diameter of the tube ranges from 1.50mm to 5.00mm, the wall thickness ranges from 0.05mm to 1.00mm, and the radial strength ranges from 240kpa to 280kpa. The invention further provides a completely biodegradable polymer stent prepared by the deformed polymer tube, the completely biodegradable polymer stent has good radial strength and toughness, instant resilience rate and later-period resistance rate of the completely biodegradable polymer stent after being implanted in a human body are reduced, and the completely biodegradable polymer stent is not easy to crack when supporting blood vessels. The deformed polymer tube is simple in preparation process, easy to be reproduced and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of preparation of medical implant stents, in particular to a deformed polymer resin pipe, a preparation method of the pipe, a device for preparing the pipe, and a fully biodegradable polymer stent prepared from the pipe. Background technique [0002] The invention relates to a radially expandable tubular device which can be implanted in the human body cavity, as well as its material and preparation method. "Tubular device" refers to an artificial device that can be implanted into the lumen of the human body; "lumen" refers to the cavity of a tubular organ, such as a blood vessel. A stent is one of the above-mentioned tubular devices, and a "stent" is usually a cylindrical device used to keep a specific section of blood vessel open or stretch it apart to treat blood vessel narrowing caused by disease. "Stenosis" refers to the contraction and reduction of the inner diameter of the tubular organ cavity in the human body...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14B29C69/02
Inventor 袁玲袁新王健胡晓露
Owner SHENZHEN SALUBRIS BIOMEDICAL ENG CO LTD
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