[C-11] CH3I iodomethane synthesizer

Abstract

The invention discloses a [C-11] CH3I iodomethane synthesizer, and belongs to the technical field of laboratory positron radionuclide tagging equipment for computer tomography; and according to the [C-11] CH3I iodomethane synthesizer, a numerical control gas flow meter is adopted to precisely control target gas containing [C-11]C02 which is produced and transmitted by a rotary accelerator into a small-volume spiral reaction tube to react with the tetrahydrofuran solution of lithium hydride aluminum. During a transmission process, low-temperature liquid is adopted to cool on line. After the raw material gas is transmitted, a heating device heats the reaction tube to a certain temperature through a method of external electric heating and internal gas heating in the shortest time, reaction solvent is removed, and waste gas passes through a buffer bottle and is collected by a gasbag. When the solvent is thoroughly removed, a reaction device is cooled by internally cooling nitrogen by a heat release-type external cooling fan, so that after the reaction tube is cooled to the appropriate temperature in the shortest time, HI acid is added in through pressure relieving nitrogen and the salt which is produced when the [C-11] C02 and the lithium hydride aluminum react is hydrolyzed and replaced, the [C-11] CH3I is produced for the marking of a C-11 compound in the next step.

Description

technical field [0001] Class of laboratory positron labeling equipment related to computed tomography. Background technique [0002] This device is used to convert [C-11]CO produced by cyclotron 2 Further synthesis of [C-11]CH 3 I, while [C-11]CH 3 I is also only an intermediate compound, and the C-11 nuclide needs to be further labeled on the final target compound before it can be used for computerized tomography of organisms. C-11 is a positron-emitting radionuclide with a half-life of only 20 minutes. If the labeling compound takes a long time, the radioactive decay will lose its use value to a certain extent. [0003] At present, the similar domestic equipment is the [C-11] methyl iodide synthesis module of Beijing Paite Biotechnology Co., Ltd. The similar equipment sold abroad to the Chinese market includes the early CTI products, the current [F-18] fluoro-[C-11] carbon integrated machine of Japan’s Sumitomo Company and the [C-11] synthesis module of GE. Among them...

AI Technical Summary

Problems solved by technology

C-11 is a positron-emitting radionuclide with a half-life of only 20 minutes. If the labeling compound takes a long time, the radioactive decay will lose its use value to a certain extent.

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