Synthesis method for trans-form amantadine compound

A technology for the synthesis of amantadine, which is applied to the preparation of organic compounds, chemical instruments and methods, and the preparation of aminohydroxyl compounds. It can solve problems such as environmental pressure, lengthy steps, and complicated operations, and achieve mild chemical reaction conditions and reduce Product loss, the effect of technological maturity
CN102503754AActive Publication Date: 2012-06-20ASYMCHEM LAB TIANJIN +4
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ASYMCHEM LAB TIANJIN
Publication Date
2012-06-20

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Abstract

The invention relates to a synthesis method for a trans-form amantadine compound, which includes the steps of utilizing commercialize raw materials on the market or an easily prepared amantadine compound as initial materials, and carrying out reductive amination reaction between the initial raw materials and liquid ammonia under the action of a reductive agent and a catalyst, so that 100% of the trans-form amantadine compound (chemical structural formula in original text) (wherein R refers to -H, -COOH, -OH, -SO2NH2 and Cl) is obtained. The method has the advantages that raw materials are easy to obtain, both reaction purity and yield are high, loss of the trans-form amantadine compound is decreased by salifying for final treatment, production cost is reduced, and the method is applicable to large-scale production and provides a novel thinking for preparing the trans-form amantadine compound.
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Description

(1) Technical field:

[0001] The invention relates to a synthesis method of amantadine, in particular to a synthesis method of trans amantadine compounds. (two) background technology:

[0002] Amantadine is an amino derivative of saturated tricyclodecane. It was first discovered in 1964 that it has antiviral effects. It is used for the prevention and early treatment of Asian influenza A virus, and later for the treatment of neurological disorders caused by Parkinson's disease. In recent years, researchers have modified and modified the chemical structure of amantadine, synthesized a series of analogs of amantadine, and found a series of compounds with better efficacy than amantadine and less toxic and side effects, suitable for primary Parkinson's disease, Parkinson's syndrome after encephalitis, drug-induced extrapyramidal reaction, Parkinson's syndrome after carbon monoxide poisoning, and Parkinson's syndrome in the elderly with cerebral arteriosclerosis, such as memantine ...

Claims

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