34 results about "Amantidine" patented technology

The present invention belongs to the field of chemically synthesized medicine and its preparation process. The medicine of the present invention is synthesized with amantadine, moroxydine, 5-Fu (5-Fc), isoniazid and other clinical medicine and polyoxometallate, and through self-assembling. The said polyoxometallate includes heteropoly acid salts of Keggin type with chemical expression XM12O40n-, Dowson type X2M18O62n- and of chemical expression LnW10O36n-. The combined use of said medicines and polyoxometallate has obvious curative effect on intractable streptococcus pneumoniae infection.

The invention discloses a process for preparing amantadine hydrochloride with high yield. The process comprises the steps of (1) preparing 1-acetamidoadamantane; and (2) preparing amantadine hydrochloride. By using the process, amantadine hydrochloride is prepared in one reaction kettle, so that the operation step is simplified; in addition, the reaction effect is promoted due to the adoption of a phase-transfer catalyst, the conversion rate and yield of the reaction can be increased due to the adoption of a solvent system selected after screening, and the cost, energy consumption and environment pollution are reduced.

The invention relates to organic synthesis, in particular to a synthetic method of amantadine hydrochloride. The technical route mainly adopted by the method is as follows: adamantane and acetonitrileare subjected to a Ritter reaction in an acid medium, and a pure amantadine hydrochloride product is obtained through hydrolysis and purification. Compared with the prior art, by adopting a special process and components, amantadine hydrochloride with high yield is prepared, can be used for preparing medicines, has the effects of treating and preventing viral infection, and has important clinicalvalue and market value; the mutual synergistic effect of various components is utilized, the amantadine hydrochloride synthesis process is effectively improved, the amantadine hydrochloride synthesisprocess is green and environmentally friendly, solvents can be recycled, waste gas is remarkably reduced, the problem of environmental pollution in the amantadine hydrochloride synthesis process of atraditional process is effectively solved, the wastewater amount is greatly smaller than that of a previous technical route, and the amantadine hydrochloride synthesis process has good industrial application potential.

The invention provides a method for preparing compound paracetamol and amantadine hydrochloride pills. The compound paracetamol and amantadine hydrochloride pills are prepared from chlorpheniramine maleate, calculus bovis factitius, caffeine, amantadine hydrochloride, paracetamol and dextrin in parts by mass. The compound paracetamol and amantadine hydrochloride pills comprise core pills, a spraying layer and an outer layer which are prepared in sequence. The process comprises the following steps: respectively connecting the outlet side of an A-grade mixing unit with a feeding hole and a third coating section of a granulation unit D through a tee joint with a valve. According to the technical scheme provided by the invention, the defects that the mixing units are uneven in mixing and the components are not uniformly distributed in a standby state in the preparation process are overcome, unified coordination management among various production steps is lacked, and the production efficiency is greatly improved.

The invention relates to a compound paracetamol and amantadine hydrochloride composition, which comprises, by weight, 200-300 parts of paracetamol, 80-120 parts of amantadine hydrochloride, 12-18 parts of caffeine, 8-12 parts of artificial bezoar, 1-3 parts of chlorpheniramine maleate, and 200-400 parts of seaweed polysaccharide. According to the present invention, the component ratio is adjusted on the basis of the pharmaceutical components of the conventional paracetamol and amantadine hydrochloride composition, and the specific proportion of the seaweed polysaccharide is added, such that the obtained composition can provide good protection effect on the immune liver injury caused by acetaminophen, and can reduce the degree of liver injury caused by paracetamol.

The invention relates to a preparation method of new low permeability reservoir water lock release agent, which uses 2,4-difluorobenzyl chloride and amantadine as main raw materials. Ethanol is used as solvent and reaction medium, potassium hydroxide is used as catalyst, and 2,4-difluorobenzyl chloride and amantadine are reacted in a ratio of 3: 1 to quaternize the amino group of amantadine to prepare a water-soluble molecule with certain monodisperse properties. The molecular aqueous solution has low viscosity and strong permeability, has excellent water locking unlocking ability for low permeability water locking cores, and has reliable preparation process, thus providing a new preparation method for ultra-low permeability reservoir water locking unlocking agent.

This invention relates to a method for synthesizing compounds containing azidotriazine amantadine, whose molecular formulae are shown in formulae I and II. The method comprises: reacting dichlorotriazine amantadine and hydrazine hydrate in a mixture of water and organic solvent by nycleophilic substitution, reacting with sodium nitrite in HCl solution to oxidize hydrazine into azide, extracting the product with ethyl acetate for three times, spin-evaporating to concentrate and obtain white product, dissolving in ethyl acetate, and slowly volatilizing to obtain single crystal of the product. The introduction of amantadine into the synthesized compounds has stable thermodynamic properties, and can release stress energy during thermal decomposition to form intramolecular hydrogen bonds, thus lowering sensitivity and improve thermal stability. The new compounds can be used in high-energy insensitive dynamites, low-signal propellants, gas generators, smoke powder and firecrackers. The method has such advantages as simple process, easy purification, no need for nitrogen protection, and no pollution.

Provided herein are oral pharmaceutical compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, and which have a low level of organic solvent. Provided are also methods of orally administrating a composition comprising amantadine, or a pharmaceutically acceptable salt thereof, to a subject, which has reduced gastrointestinal side effects or sleep disturbances. Further provided are extended release oral compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, that are suitable for once daily administration.

The invention discloses an anti-amantadine AMD single-chain antibody, and a preparation method and application thereof. According to the invention, a heavy-chain variable region gene and a light-chainvariable region gene of the antibody can be obtained from a hybridoma cell strain 3F2 of a monoclonal antibody secreting amantadine (AMD) through a genetic engineering mean; and after the two genes are recombined, a prokaryotic expression plasmid vector is constructed, and escherichia coli is transformed to express scFv antibody active fragments capable of specifically recognizing the AMD. Experiments prove that the recombinant single-chain antibody scFv prepared by the method has specific recognition and binding activity withamantadine. Residual detection of amantadine can be realized through utilization of recognition and binding activity of the recombinant single-chain antibody on amantadine, and the constructed transformation vector plasmid is easy for storage and mass-produce.

A method for preparing amantadine includes chlorinating adamantane with chlorine gas in a solvent in the presence of a Lewis acid catalyst to obtain a reaction liquid, and then removing the solvent and residues containing the catalyst in the reaction liquid, to obtain a chlorinated product. The chlorinated product is mixed with urea to a mixture, and the mixture is subjected to an amination reaction, to obtain amantadine. The results of examples show that the purity of the prepared amantadine could reach 99.5% or more.

The invention relates to a traditional Chinese and western medicine pharmaceutical composition for inhibiting novel coronavirus, belonging to an antiviral traditional Chinese and western medicine pharmaceutical composition. The pharmaceutical composition comprises beta-podophyllopodophyllin, forsythin, ritonavir, amantadine and the like, has an inhibition effect on the activity of topoisomerase, can interfere the functions of nucleoprotein bodies, inhibit influenza virus neuraminidase and prevent RNA (Ribonucleic Acid) viruses from penetrating host cells, and has an inhibition effect on novel coronavirus COVID-19.

The invention discloses a preparation method of high-purity amantadine hydrochloride. The method comprises the following steps: extraction: extracting the reacted material in the amantadine hydrochloride production process with extraction oil, and standing for layering; washing with water, layering, transferring into a washing kettle, and removing acid and impurities; crystallizing, transferring into a crystallization kettle, crystallizing, and drying the extract oil by a centrifuge to obtain a crude product; washing, separating the crude product by a centrifuge, drying the extract oil to obtain a crude product, putting the crude product into a washing kettle, adding a detergent, stirring and washing; and separating, separating the material from water by using a full-automatic self-discharging centrifuge to obtain a refined product, putting the refined product into a double-cone drying machine, drying, and packaging to obtain a finished product. In actual use, discharged wastewater isreduced, the water yield is low after the process is improved, the wastewater can be recycled in production, zero emission is achieved, and the purity of amantadine hydrochloride is improved to 99.96%from 99.15%; the maximum single impurity content is reduced from 0.26% to 0.03%; amantadine hydrochloride meets the requirements of most samples and reagents, and the recovery rate of amantadine hydrochloride is 89.5%.

The invention discloses an amantadine hydrochloride impurity removal method, and relates to the technical field of chemical synthesis. The problem that waste gas and waste water are generated by usingfuming sulfuric acid is solved. The preparation method specifically comprises the following steps: taking 15g of refined bromo-amantadine and 10g of urea, stirring, mixing and grinding, and sieving with a 200-mesh sieve; transferring the mixture into a 100ml three-necked bottle, and adding 40ml of soybean oil; heating the oil bath to 140 DEG C, putting the oil bath into a three-neck bottle, continuously heating to 160 DEG C, keeping the temperature, reacting to 190 DEG C, and stopping heating after the reaction is finished. Brominated amantadine and urea are used as raw materials, soybean oilis used as a solvent, the reaction temperature is controlled to be 160 DEG C, the synthesis process of amantadine hydrochloride is improved, an impurity-removed pure amantadine hydrochloride productis obtained through hydrolysis, decoloration and purification, generation of waste gas is effectively reduced, and the problem of environmental pollution in the amantadine hydrochloride synthesis process is solved; compared with the prior art, wastewater is greatly reduced.

The invention discloses an intelligent GO (graphene oxide) drug carrier with supermolecule sensitive detaching capacity, a preparation method and an application. Carboxylic amantadine is dissolved in dichloromethane, then EDC and NHS are added, and a solution is obtained after stirring; cystamine is dissolved in dichloromethane, an obtained mixture is added to the solution, amantadine containing a disulfide bond is obtained, EDC is dissolved in water, an obtained mixture is added to a GO-COOH suspension, NH2-SS-PEG-Ad is added after ultrasonic processing, dialysis is performed after stirring, and GO modified with amantadine containing the disulfide bond is obtained; NGO-SS-Ad is mixed with a cyclodextrin suspension, and cyclodextrin modified GO is obtained after oscillation. The synthesized supermolecular functionalized GO core-shell nano-drug carrier supports a hydrophobic drug with a large pi conjugated structure under pi-pi interaction and hydrophobic interaction, the disulfide bond can be dissociated rapidly in internal environment of tumor cells, supermolecule detaching is realized, and the function of intelligent drug release is realized.

The invention discloses a dual-purpose test strip for detecting enrofloxacin and amantadine and a preparation method and a detection method of the dual-purpose test strip, and relates to the technical field of molecular detection. Two substances of amantadine and enrofloxacin can be detected at the same time through the two detection lines, no instrument or equipment is needed, operation is easy, convenient and rapid, the result can be read through naked eyes during manual operation,and the efficiency of on-site detection of residual standard exceeding of amantadine and enrofloxacin is greatly improved. The dual-purpose test strip has a wide prospect in rapid immunodetection application of enrofloxacin and amantadine drugs, and meanwhile, the proposal of the dual-purpose test strip also provides strong guarantee for market monitoring. The test strip has the advantages of good specificity and good stability. In addition, the invention further provides a method for detecting enrofloxacin and/or amantadine, and the detection method can meet the requirement for rapid and accurate detection of enrofloxacin and amantadine.