Production process of dry cephalosporin C sodium salt

A cephalosporin and production process technology, which is applied in the production process field of dry cephalosporin C sodium salt, can solve problems such as dangerous production conditions, and achieve the effects of reducing production cost, short technological process and saving alcohol

Inactive Publication Date: 2012-06-20
SHANDONG LIHAIRUN BIOLOGICAL TECH
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  • Summary
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  • Application Information

AI Technical Summary

Problems solved by technology

This process requires a large amount of alcohol as a solvent in the later stages of crystallization, centrifugal drying, and flash drying. The alcohol is emitted into the air during centrifugation, and the production conditions are extremely dangerous.

Method used

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Embodiment Construction

[0009] The production technique of dry cephalosporin C sodium salt of the present invention, when concrete production, operates according to the following steps:

[0010] The first step, nanofiltration concentration: the cephalosporin C sodium salt decolorization solution is subjected to four-stage concentration through a nanofiltration membrane device with a molecular weight of 200 Daltons. The temperature of the concentration process is controlled between 7°C-10°C, and the concentrated The titer of the filtrate is between 130000ug / ml-160000ug / ml, and the solid content is between 15%-18.5%.

[0011] The second step, drying: transport the concentrated liquid to the centrifugal spray dryer with a screw pump, and control the inlet air temperature at 155°C-165°C. The outlet air temperature is between 75°C and 90°C. The material stays in the drying tower chamber for 8-12 seconds, and is quickly taken out through the cyclone separator for separation and collection, and is sent to ...

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PUM

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Abstract

The invention discloses a production process of a dry cephalosporin C sodium salt. The production process comprises the following steps of: 1, performing nano-filtration concentration; 2, drying: conveying a concentrated solution into a centrifugal spray drier by using a screw pump, controlling an air inlet temperature at 155-165 DEG C, controlling the air outlet temperature at 75-90 DEG C, retaining a material in the tower chamber of a drying tower for 8-12 seconds, quickly extracting the material, separating and collecting with a cyclone separator, inspecting, and feeding the qualified material to packaging equipment, wherein inspection qualification standards are that: (1) property: slightly yellow crystalline powder; (2) moisture is less than or equal to 6.0 percent; (3) a color grade is less than or equal to Y-7; and (4) the purity of cephalosporin C is more than or equal to 86 percent; and III, packaging: metering a finished product, bagging, sealing and warehousing. The production process has the beneficial effects that: (1) the process flow is short, and the production efficiency is high; and (2) a large amount of alcohol is saved, production cost is reduced, and potential safety hazard is reduced.

Description

technical field [0001] The invention discloses a production process of dry cephalosporin C sodium salt. Background technique [0002] At present, the extraction process of cephalosporin C sodium salt is that after the fermented liquid is ultrafiltered, it enters the resin for analysis, extraction, and decolorization to form a cephalosporin C sodium salt decolorization solution, which is then concentrated by nanofiltration, crystallized, centrifugally dried, Flash dry. This process requires the use of a large amount of alcohol as a solvent in the later stages of crystallization, centrifugal drying, and flash drying. The alcohol is emitted into the air during centrifugation, and the production conditions are extremely dangerous. Contents of the invention [0003] The problem to be solved by the present invention is: to provide a four-step process of nanofiltration, crystallization, centrifugal drying, and flash drying into a two-step process of nanofiltration and drying, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/28C07D501/12
Inventor 刘祎祯张岩郭祥方李同振
Owner SHANDONG LIHAIRUN BIOLOGICAL TECH
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