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Method for detecting nicotine release behavior of gum base type smoke-free tobacco product

A technology for smokeless tobacco and tobacco products, which is applied in the field of tobacco, can solve the problems of controlling human body damage and difficulty in experimentation, and achieves the effects of easy promotion, good repeatability, and short detection cycle

Active Publication Date: 2012-06-20
ZHENGZHOU TOBACCO RES INST OF CNTC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The experimental results of this method are easily affected by the individual physiological differences of the volunteers and the habit of consuming tobacco products. The experiment is not easy to control and has great harm to the human body.

Method used

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  • Method for detecting nicotine release behavior of gum base type smoke-free tobacco product
  • Method for detecting nicotine release behavior of gum base type smoke-free tobacco product
  • Method for detecting nicotine release behavior of gum base type smoke-free tobacco product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Test sample: Nicorette Classical 4mg Gum (Sweden). The pH of the artificial saliva was 6.7, the initial volume of artificial saliva in the small bowl was 20 mL, the flow rate of the peristaltic pump was 20 mL / min, and the test was carried out for 60 min. The nicotine release fluid and fresh artificial saliva were extracted at 2 min, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 35 min, 40 min, 45 min, 50 min, and 55 min of the experiment , the amount of extraction and supplementation of artificial saliva is 5 mL, and the order of extraction and supplementation is followed; the system automatically stops at 60 minutes, and the peristaltic pump draws the last release fluid. Take out the residual gum base sample, put it into a 100 mL Erlenmeyer flask, add 5.0 mL of n-hexane, cover the stopper, and shake it on a shaker for 15 min. After the gum base sample is completely dissolved, add 40 mL of mixed phosphate Buffer solution (pH = 6.86), placed on the shaker again for 30 ...

Embodiment 2

[0040] Test sample: Nicotinell Fruit 4mg Medicated Chewing Gum (Germany). The pH of the artificial saliva was 6.7, the initial volume of artificial saliva in the small bowl was 10 mL, and the peristaltic pump continuously updated the artificial saliva in the simulated chewing machine at a flow rate of 2.5 mL / min. The test was carried out for 30 minutes. The nicotine release solution was collected every 2 minutes. The peristaltic pump was turned off at 28 minutes, and the system automatically stopped at 30 minutes. At this time, the last release solution was collected manually. The residual sample was treated in the same manner as in Example 1. The nicotine content in the nicotine release liquid and the residual sample extract was detected by high performance liquid chromatography, and the chromatographic conditions were the same as in Example 1. Calculate the cumulative release rate of nicotine based on the quantitative results, and draw the nicotine release curve of the toba...

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Abstract

The invention discloses a method for detecting a nicotine release behavior of a gum base type smoke-free tobacco product. The method for detecting the nicotine release behavior of the gum base type smoke-free tobacco product is characterized by being capable of simulating the release condition of nicotine in the gum base type tobacco product when the tobacco product is chewed in the mouth of a person and performing real-time and quantitative detection on a release amount and a release speed. The method comprises the specific steps of: (1) releasing and collecting nicotine in vitro; (2) performing quantitative analysis on the content of the nicotine in collected liquid and residual samples; and (3) drawing an in-vitro nicotine release curve. The method can be used for detecting the nicotine release speed and the nicotine release degree of the gum base type tobacco product so as to provide the technical support for researching and judging the safety of the gum base type smoke-free tobacco product and performing quality regulation and control. The method is close to the true condition of the gum base type smoke-free tobacco product consumed by the person, is rapid and exact, good in repeatability and short in detection period, is suitable for detection of the gum base type smoke-free tobacco product in various sizes and is convenient to popularize.

Description

[0001] technical field [0002] The present invention relates to the field of tobacco, in particular to a method for detecting the nicotine release behavior of gum-based smokeless tobacco products, by which the safety and quality of gum-based smokeless tobacco products can be studied or measured Regulation provides specific data support. Background technique [0003] Gum-based smokeless tobacco products are chewing tobacco products with added tobacco extracts. The biggest difference between such products and cigarettes is that they are smokeless tobacco products. When used, like chewing gum, through chewing, the tobacco components such as nicotine contained in such tobacco products are dissolved in saliva and then absorbed by the body through the oral mucosa. [0004] In recent years, due to the restrictions on smoking in public places by governments of various countries, the consumption of smokeless tobacco products has been increasing year by year, especially gum-based t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 张建勋张文娟李鹏曾波慎龙舞宗永立黄卫东
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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