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Sustained-release pearl clear-sighted eye drops and preparation method thereof

An eye drop, slow-release technology, which is applied in the direction of medical formula, unknown raw materials, medical preparations containing active ingredients, etc., can solve the problems of drug side effects, frequent administration of pearl eye drops, etc., to achieve release The effect of drug uniformity and prolonging the time of drug concentration

Active Publication Date: 2013-10-30
苏州工业园区天龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a sustained-release pearl eye drop for improving eyesight and its preparation method. The preparation process is simple and can solve the problems of frequent administration of the original pearl eye drop for improving eyesight and drug side effects.

Method used

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  • Sustained-release pearl clear-sighted eye drops and preparation method thereof
  • Sustained-release pearl clear-sighted eye drops and preparation method thereof
  • Sustained-release pearl clear-sighted eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Sustained-release pearl eye drops and preparation method thereof

[0032] (1) Prescription: The specific composition of each 1000mL is:

[0033] Pearl liquid 20mL,

[0034] borneol 1.0g,

[0035] Ethylparaben 0.5g,

[0036] Hydroxypropyl Beta Cyclodextrin 8g,

[0037] Propylene glycol 5mL,

[0038] Sodium chloride 8.9g,

[0039] The rest is water for injection.

[0040] (2) Preparation of pearl liquid: Weigh 500g of pearl powder, add it to 2000mL of water for injection, heat to 95-100°C, keep warm for 2 hours, then cool to about 60°C, stop stirring for 1 hour, and separate the supernatant liquid, concentrated to 500mL, and then filtered through a plate-and-frame filter with a 0.45 μm microporous membrane to obtain pearl liquid, and the protein content of the pearl liquid was determined to be 1.5 mg / mL.

[0041] (3) Preparation of slow-release Pearl Eye Drops: ①Add 8.9g of sodium chloride to an appropriate amount of water for injection, heat to boil, ...

Embodiment 2

[0042] Embodiment 2 Sustained-release pearl eye drops and preparation method thereof

[0043] (1) Prescription: The specific composition of each 1000mL is:

[0044] Pearl liquid 20mL,

[0045] borneol 1.0g,

[0046] Ethylparaben 0.5g,

[0047] Hydroxypropyl Beta Cyclodextrin 10g,

[0048] Propylene glycol 3mL,

[0049] Sodium chloride 8.9g,

[0050] The rest is water for injection.

[0051] (2) Preparation of pearl liquid: Weigh 500g of pearl powder, add it to 2000mL of water for injection, heat to 95-100°C, keep warm for 2 hours, then cool to about 60°C, stop stirring for 1 hour, and separate the supernatant liquid, concentrated to 500mL, and then filtered through a plate-and-frame filter with a 0.45 μm microporous membrane to obtain pearl liquid, and the protein content of the pearl liquid was determined to be 1.5 mg / mL.

[0052] (3) Preparation of slow-release Pearl Eye Drops: ①Add 8.9g of sodium chloride to an appropriate amount of water for injection, heat to boil,...

Embodiment 3

[0053] Example 3 Pharmacokinetic Comparison of Different Types of Pearl Eye Drops

[0054] (1) Purpose of the test

[0055] In this test, taking the representative ingredient borneol in the medicine as an index, the slow-release pearl eye drops sample of the invention embodiment 1, the common pearl eye drops, the thickened pearl eye drops, and different Comparing single-dose pharmacokinetics and drug-release properties of inclusion-type pearl eye drops containing propylene glycol in rabbit tears to investigate their advantages and disadvantages.

[0056] (2) Experimental plan

[0057] drug:

[0058] ① slow-release pearl eye drops of the present invention: prepared according to the above-mentioned embodiment 1;

[0059] ②Inclusion type pearl eye drops: except that propylene glycol is not added, the preparation method is prepared according to Example 1;

[0060] ③ Ordinary pearl eye drops (Suzhou Industrial Park Tianlong Pharmaceutical Co., Ltd., batch number: 110405);

[0...

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PUM

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Abstract

The invention discloses sustained-release pearl clear-sighted eye drops and a preparation method thereof. Specifically, hydroxypropyl-beta-cyclodextrin and propylene glycol are added into the prescription of the eye drops, so that medicaments are uniformly released, the action time of the medicaments is prolonged, irritative reaction caused by borneol and ethanol can be reduced, and the aims of improving medicinal cure effects and lowering medicament side effects are fulfilled.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a sustained-release pearl eye drop for improving eyesight and a preparation method thereof. Background technique [0002] Pearl eye drops are composed of pearl liquid, borneol, ethylparaben and auxiliary materials such as ethanol and sodium chloride. It has the effects of clearing away heat and purging fire, nourishing the liver and improving eyesight, and reducing inflammation. It is mainly used for visual fatigue and chronic conjunctiva in clinical practice. It can improve symptoms such as eye swelling, eye itching, eye pain, dry eyes, astringent eyes, and inability to read for a long time. [0003] At present, Zhuzhu Mingmu Eye Drops is a commonly used drug in ophthalmology, and the clinical demand is relatively large, but there are also some problems in the clinical use of the preparation: (1) frequent medication, which brings inconvenience to the patient's use (its...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K35/56A61K47/40A61P27/02A61K31/045A61K31/235A61K35/618
Inventor 范弋汤国平陈业仓郑云枫彭国平
Owner 苏州工业园区天龙制药有限公司
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