Arrangement and method using microsensors for measuring cell vitalities

A cell activity, sensor technology, applied in measurement devices, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve problems such as high space consumption, and achieve the effect of reliable recording and reliable measurement

Active Publication Date: 2012-07-04
BOEHRINGER LNGELHEIM VETMEDICA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, the implementation of operational amplifie

Method used

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  • Arrangement and method using microsensors for measuring cell vitalities
  • Arrangement and method using microsensors for measuring cell vitalities
  • Arrangement and method using microsensors for measuring cell vitalities

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Embodiment Construction

[0035] figure 1 The arrangement formed by the cells 4 arranged in the array of magnetic particles 3 above the sensors 2 of the sensor array is shown in a cross-sectional view. The sensor array is formed on a semiconductor chip 1 which includes integrated circuits for performing electrochemical measurements by means of sensors 2 . The magnetic particles 3 are magnetically immobilized on the surface of the chip 1 in the form of a layer of substantially uniform thickness by means not shown that generate a magnetic field. The cells 4 can be connected to the magnetic particles 3 or grown onto the particles, for example via antibodies. The magnetic particles 3 have dimensions in the micrometer or nanometer range, and the cells have dimensions in the micrometer range. In the case of living cells, the consumption of metabolites and substances required for metabolism, such as oxygen, can be measured in the immediate surroundings 5 ​​of the cells 4 .

[0036] The sensor 2 for the ele...

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Abstract

The present invention comprises an arrangement and a method for measuring cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip (1), wherein the semiconductor chip (1) comprises integrated circuits and an integrated circuit is associated with each sensor (2) of the sensor array, for processing the measurement signals of the respective sensor (2). The integrated circuits are formed in the semiconductor chip (1) spatially in each case below the associated sensor (2) and neighbouring sensors (2) of the sensor array have a centre-to-centre spacing of the neighbouring sensors (2) in the range of micrometres. The pH and/or pO2 can be measured in the environment of a living cell (4).

Description

technical field [0001] The present invention relates to a device and method for measuring cell activity using a sensor array. The sensor array is formed on the surface of a semiconductor chip, wherein the semiconductor chip includes integrated circuits and one integrated circuit per sensor of the sensor array for processing the measurement signals of the individual sensors. The integrated circuits are designed so that they are spatially located in each case below the corresponding sensor in the semiconductor chip. Can measure pH and / or pO in the context of living cells 2 value. Background technique [0002] Numerous methods are known in microorganisms for the detection of pathogenic germs based on cell culture and antibiotic resistance tests. An advantage of the "phenotypic" approach is that in this approach effects such as growth or inhibition of cell growth are examined. A direct reference to the effect on humans or animals can be obtained by the effect on cell culture...

Claims

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Application Information

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IPC IPC(8): G01N27/416C12M1/34G01N33/487
CPCC12M41/38C12M41/46G01N27/416G01N27/404G01N27/423G01N33/48735
Inventor W.甘姆布雷切特M.施恩勒A.弗雷P.鲍里卡D.斯科特M.斯坦泽尔
Owner BOEHRINGER LNGELHEIM VETMEDICA GMBH
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