Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sheet-form preparation and method for producing the same

A preparation and tablet technology, applied in the field of gel-type tablet preparations, can solve problems such as difficulty in maintaining the shape

Inactive Publication Date: 2012-07-11
NITTO DENKO CORP
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, when the drug is in liquid form, the tablet preparation may dissolve, so it may be difficult to maintain a constant shape

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sheet-form preparation and method for producing the same
  • Sheet-form preparation and method for producing the same
  • Sheet-form preparation and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] 3 parts by weight of crystalline cellulose A (average particle diameter: 20 μm) was added to 74 parts by weight of purified water, and ultrasonic dissolution and dispersion were performed. Add 10 parts by weight of water-soluble gelatin (about 100,000 average molecular weight, about 8.6 mol% of hydroxyproline) derived from fish (tilapia) therein, dissolve it at a temperature of normal temperature to 40° C., and further add Add 10 parts by weight of D-sorbitol, 3 parts by weight of PEG4000 to make it dissolve, and distribute 1g to 5cm 2 The plastic blister (Cryomold (square) No. 3, manufactured by Sakura Finetek Japan Co., Ltd.) was cooled and solidified at 2 to 8°C for 1 day and night to obtain a sheet-like preparation.

Embodiment 2

[0107] 3 parts by weight of crystalline cellulose A (average particle diameter: 20 μm) was added to 74 parts by weight of purified water, and ultrasonic dissolution and dispersion were performed. 10 parts by weight of gelatin (derived from fish) (average molecular weight: 100,000, hydroxyproline content about 8.6 mol%) was added thereto, dissolved at a temperature of 50 to 70°C, and vibrated at a constant temperature of 40°C. In this solution, add 10 parts by weight of D-sorbitol, 3 parts by weight of PEG4000 to make it dissolve, and distribute 1g to 5cm 2 The plastic blister (Cryomold (square) No. 3, manufactured by Sakura Finetek Japan Co., Ltd.) was cooled and solidified at 2 to 8°C for 1 day and night to obtain a sheet-like preparation.

Embodiment 3～7

[0109] Except having adopted the composition shown in Table 1, it operated in the same procedure as Example 2, and obtained the sheet-form preparation.

[0110] Use gelatin (pig origin) A (average molecular weight about 85,000, hydroxyproline amount about 9.2 mole %) in embodiment 3, use alkali treatment gelatin (pig origin) (average molecular weight 180,000, hydroxyproline amount) in embodiment 4 Acid amount is about 9.2 mol%), acid-treated gelatin (porcine origin) is used in Example 5 (average molecular weight 100,000, hydroxyproline amount is about 9.2 mol%), and gelatin (porcine origin) B (average Molecular weight about 100,000, hydroxyproline content about 9.4 mol%), gelatin (bovine origin) was used in Example 7 (average molecular weight about 200,000, hydroxyproline content about 9.5 mol%).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
areaaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The present invention provides a sheet-form preparation and method for producing the same. The sheet-form preparation can be easily dissolved in a mouth, allows the dissolution time thereof to be easily controlled, and can stably contain a drug except an allergenic protein from cedar pollen. The sheet-form preparation is characterized by containing water, gelatin, and a drug except an allergenic protein from cedar pollen.

Description

technical field [0001] The present invention relates to a jelly-type sheet preparation that dissolves in the oral cavity and a method for producing the sheet-like preparation containing a drug other than cedar pollen allergenic protein. Background technique [0002] Currently, as pharmaceutical preparations for oral administration, there are, for example, uncoated tablets, coated tablets, capsules, powders, granules, liquids and the like on the market. In addition, orally disintegrating tablets and orally dissolving films are commercially available as preparations that disintegrate in the oral cavity and are absorbed in the digestive tract. [0003] Dosage forms that are disintegrated or dissolved only by saliva without being chewed in the mouth, and which improve the benefits of patients and caregivers are attracting attention. With the increase of the elderly population, the number of patients with so-called mastication / swallowing difficulties who have difficulties in int...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61P37/08
CPCA61K31/00A61K47/42A61K47/26A61K38/014A61K9/0056A61K9/7007A61P37/08A61K9/70
Inventor 浅利大介宍户卓矢堀光彦冈崎俊彦
Owner NITTO DENKO CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com