Liquid filtering device and filtering method thereof

A liquid and shell technology, which is applied in the field of liquid filtration devices, can solve the problems of time-consuming operation, cumbersome process steps, non-compliance with application costs, large sample consumption, etc., to avoid excessive length, low sample consumption, and simple structure. Effect

Inactive Publication Date: 2012-07-11
NAT CHENG KUNG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the biggest problem with this technology is the formation of filter cake on the surface of the membrane. Especially with the increase of blood flow, the thickness of the filter cake will inevitably increase correspondingly, so that it must be washed and removed every time it is used, which costs a lot. more manpower
In addition, and more importantly, deep filtration often creates greater pressure on the blood cells in the blood, causing hemolysis during the filtration process, resulting in failure of the separation operation
[0007] Based on the above, it is obvious that the known technology of separating blood cells to obtain plasma inevitably has problems such as large sample consumption, expensive equipment that does not meet the application cost, long operation time and / or cumbersome process steps. Therefore, how to provide a low-cost, A liquid filtration device with a simple structure not only responds quickly, but also requires a small amount of sample, and its operation is economical. More importantly, it can effectively avoid the formation of filter cake and hemolysis, which has become an important issue.

Method used

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  • Liquid filtering device and filtering method thereof
  • Liquid filtering device and filtering method thereof
  • Liquid filtering device and filtering method thereof

Examples

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Effect test

experiment example 1

[0079] Experimental Example 1 Utilizes the device of the present invention to filter human blood

[0080] The device of the present invention made according to the aforementioned method is a micro biochip here. First, 0.5 mL of human whole blood was measured with a 1 mL syringe. The whole blood is injected into the device of the present invention by using a Teflon joint to connect the injection syringe. Adjust the microinjection pump to maintain a flow rate in the range of 0.05 mL / min to 0.5 mL / min. The set of flow rate settings used here can be 0.5 mL / min, 0.3 mL / min, 0.1 mL / min, 0.07 mL / min, and 0.05 mL / min. The injection can be completed within about 10 minutes of continuous input. Observation of filtering results by optical microscope, such as Figure 8 As shown, the blood flow channel C can be observed under a 10X microscope, and the separation of plasma and blood cells occurs through the filter membrane (as indicated by the arrow D).

[0081] In summary, because the...

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Abstract

The invention provides a device used for filtering a liquid. The device includes a flow channel and a filtering film. The flow channel is provided with an inlet and an outlet. The filtering film is provided with a plurality of holes. The flow channel is arranged on the filtering film in an overlapping manner. And when the liquid flows through the flow channel, the liquid contact with the filtering film. The device in the invention has a structure satisfying cross flow filtering principle. Thus, parallel shear stress can be generated by the liquid in the flow channel, thereby avoiding impurity accumulation in the holes of the filtering film.

Description

technical field [0001] The invention relates to a liquid filtering device and a filtering method thereof. Background technique [0002] Blood is responsible for the important work of oxygen and energy transmission in organisms, and is one of the indispensable elements for the normal operation of life systems. Based on this point, various blood-centered application technologies have been developed in the fields of clinical treatment and medical testing, hoping to further solve the discomfort caused by illness through accurate and rapid acquisition / analysis of cells or substances contained in blood. Improve the quality of human life. Under this concept, blood separation or filtration technology, which is the basis of many advanced applications, has always been regarded as one of the key development projects. [0003] At present, known techniques for separating blood cells and plasma can be mainly divided into four categories. The first is centrifugation technology. Through ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/00
Inventor 林裕城叶家显洪家纬陈克戎
Owner NAT CHENG KUNG UNIV
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