Swertia mileensis dispersible tablet and preparation method thereof

A technology of green leaf gallbladder and dispersible tablets, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve the problems of incomplete extraction of active ingredients, delayed disintegration, and low efficacy.

Active Publication Date: 2012-07-25
GUIPING PRODIVITY PROMOTION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing gallbladder preparations are prepared by traditional techniques, and there are deficiencies such as incomplete extraction of active ingredients, low content of active ingredients, slow disintegration, and low curative effect.

Method used

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  • Swertia mileensis dispersible tablet and preparation method thereof
  • Swertia mileensis dispersible tablet and preparation method thereof
  • Swertia mileensis dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1570g of Foliage gallbladder, crush it into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 20Mpa, the extraction temperature is 20°C, the separator pressure is 10Mpa, the separator temperature is 40°C, the separation time is 2 hours, and the flow of carbon dioxide per hour 20L to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; add 80g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 35g, crospovidone 35g, croscarmellose sodium 35g, hypromellose 25g, micropowder silica gel 15g, sodium chloride 5g, mannitol 4g, lactose 4g, mix well, Wet granulate with 50% ethanol, dry at 60°C, add 7g of sodium carboxymethyl starch, 1g of magnesium stearate, granulate, press into 1000 pieces, and...

specific Embodiment 2

[0023] Take 1570g of Foliage gallbladder, crush it into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 40Mpa, the extraction temperature is 40°C, the separator pressure is 20Mpa, the separator temperature is 60°C, the separation time is 4 hours, and the flow rate of carbon dioxide per hour 40L to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; add 120g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 45g, crospovidone 45g, croscarmellose sodium 45g, hypromellose 35g, micropowder silica gel 25g, sodium chloride 15g, mannitol 6g, lactose 6g, mix well, Wet granulate with 70% ethanol, dry at 80°C, add 9g of sodium carboxymethyl starch, 3g of magnesium stearate, granulate, press into 1000 piec...

Embodiment 3

[0025] Take 1570g of Foliage gallbladder, crush it into 60 mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 30Mpa, the extraction temperature is 30°C, the separator pressure is 15Mpa, the separator temperature is 50°C, the separation time is 3 hours, and the flow rate of carbon dioxide per hour 30L to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 100g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 40g, crospovidone 40g, croscarmellose sodium 40g, hypromellose 30g, micropowder silica gel 20g, sodium chloride 20g, mannitol 5g, lactose 5g, mix well, Wet granulate with 60% ethanol, dry at 70°C, add 8g of sodium carboxymethyl starch, 2g of magnesium stearate, granulate, press into 1000 pieces...

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Abstract

The invention discloses a swertia mileensis dispersible tablet and a preparation method thereof. The preparation method is characterized by comprising the following steps: extracting swertia mileensis by adopting a carbon dioxide supercritical extraction method; drying at reduced pressure; crushing the swertia mileensis into nano-paste by using a high-energy nano-impact mill; adding a functional auxiliary material to prepare the swertia mileensis dispersible tablet. By adopting the preparation method, the contents of effective components are remarkably improved, the disintegration time is remarkably shortened, the curative effect is remarkably superior to the swertia mileensis tablet, and a positive effect is obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Qingyedan ​​dispersible tablet and a preparation method thereof. Background technique [0002] Foliage Gallbladder has the effects of clearing the liver and gallbladder, clearing heat and promoting dampness, and is used for the treatment of icteric hepatitis and viral hepatitis. The existing gallbladder preparations are prepared by traditional techniques, and there are deficiencies such as incomplete extraction of active ingredients, low content of active ingredients, slow disintegration, and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Qingyedan ​​dispersible tablet with complete extraction of active ingredients, high content of active ingredients, fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/20A61K47/38A61P1/16A61P31/14A61P31/20
Inventor 孙长海任恒鑫张舒婷
Owner GUIPING PRODIVITY PROMOTION CENT
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