Pressurized hot water sterilization process and equipment pipeline configuration of continuous sterilization system for aerobic microbe fermentation culture medium or fed-batch material

Abstract

The invention relates to a pressurized hot water sterilization process and equipment pipeline configuration of a continuous sterilization system for aerobic microbe fermentation culture mediums or fed-batch materials. The process comprises the following steps that: 1) a pressurized water sterilization tank is fully filled with water, g air in the tank is exhausted, water in the tank is connected with a heat exchanger A through a continuous sterilization pump and the water is heated; 2) hot water returns back to the pressurized water sterilization tank along a culture medium or fed-batch material inlet pipeline through a maintaining tank before the hot water enters a fermentation tank or a fed-batch tank, and after the designated liquid level is reached, inlet water and outlet water enter a closed circulation mode, the water is continuously and cyclically heated, the temperature of the water in the tank is continuously increased and non-condensable gas is continuously exhausted; and 3) when the temperature of the water reaches 100 DEG C, an exhaust valve is closed and corresponding internal pressure of the water sterilization tank is increased with the increase of the temperature of the water, and when the temperature of the water reaches 125-130 DEG C, the inlet water and the outlet water of the system enter a pressurized closed circulation mode and then water sterilization of the system is conducted immediately. The pressurized hot water sterilization process and the equipment pipeline configuration of the continuous sterilization system for aerobic microbe fermentation culture mediums or fed-batch materials have the advantages that the pressurized sterilizing water production process is stable, continuous and reliable, the safety of the continuous sterilization system for culture mediums or fed-batch materials in the fermentation engineering is improved, the heat loss of the pressurized sterilizing water is fewer and the energy consumption is reduced.

Description

technical field [0001] The present invention relates to the field of microbial industrial fermentation production, in particular to a process for carrying out pressurized high-temperature hot water disinfection for aerobic microorganisms in industrial production for fermentation medium or fed-in continuous disinfection and sterilization system (abbreviated as continuous disinfection system) (Also known as pressurized water disinfection) and equipment pipeline configuration Background technique [0002] Today, with the continuous development of biotechnology with fermentation engineering as the core content, the production of products by means of microbial cultivation has involved medicine, chemical industry, light industry, energy, environmental protection and other fields. As fermentation engineering tends to equipment large-scale, high efficiency and automation, Higher requirements are put forward for large-scale production process operation and equipment design. One of th...

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Problems solved by technology

[0005] Based on the characteristics of the above two disinfection systems, since domestic fermentation production enterprises cannot solve the problems existing in the water disinfection process of fermentation medium or fed-batch continuous elimination system, most enterprises use the steam elimination system process , so that the water elimination system with the characteristics of safety, stability, and easy control cannot be widely used in the fermentation industry, which greatly restricts the promotion and application of this technology in the fermentation industry

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