Automatic drug delivery system for hydroxylcamptothecin injection

Abstract

The invention discloses an automatic drug delivery system and a drug delivery method for hydroxycamptothecin injection. The automatic drug delivery system comprises an infusion module, a human-computer interaction module, a display module, a timing module, a motor execution module, an alarm monitoring module and a computer processing module. The drug delivery method includes: inputting prepared liquid medicine into the infusion module, setting or confirming drug delivery amount, drug delivery time, intermittent time, drug delivery times and alarm information; monitoring whether warning information exists or not, and if not, operating first-time drug delivery while the timing module starts timing; when the set drug delivery time is up, allowing a motor to pause to enter a low-power-consumption mode while timing is unstopped; when the set intermittent time is up, automatically increasing the drug delivery times by one, and allowing a motor module to reoperate to start next-time drug delivery; and finishing drug delivery when drug delivery times in operation is larger than the initially set drug delivery times. Using the system and the method can improve curative effects of hydroxycamptothecin and reduce drug toxic and side effects, and accordingly quality of life can be improved for patients.

Description

technical field [0001] The invention relates to a drug delivery system, in particular to an automatic drug delivery system which is specially used for hydroxycamptothecin injection and can be administered intermittently. Background technique [0002] Hydroxycamptothecin (HCPT for short) is a natural alkaloid extracted from the unique plant camptophylla in my country. It has been widely used clinically in many countries. [0003] HCPT presents a two-compartment model in vivo, t 1／2α is 0.0523-0613h,t 1／2β For 1.03-2.42h, Vd: 5.4-11.40 L, plasma protein binding rate is 65% to 99%. Bone marrow suppression is a dose-limiting adverse reaction of HCPT, manifested as neutropenia in a dose-dependent manner, and granulocytes return to normal levels within 1-2 weeks after drug withdrawal. Gastrointestinal reaction: Nausea, vomiting I-II degree, duration mostly 2-3d. Diarrhea increased with the dose, and the occurrence ratio was dose-dependent, and the degree of diarrhea was mild i...

AI Technical Summary

Problems solved by technology

[0006] However, the existing automatic drug delivery system is generally a uniform delivery of a certain dosage within a certain period of time, which is not suitable for this intermittent delivery of hydroxycamptothecin. In order to improve the curative effect and reduce adverse reactions, There is a need for an automatic dosing system for intermittent administration of hydroxycamptothecin

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