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Differential interference phase detecting method and device of vector beam excitation surface plasma

A surface plasmon and beam excitation technology, applied in the field of optical sensing and imaging of biochemical detection, can solve the problems of inability to realize real-time detection, limited dynamic range of phase modulation detection, and decreased sensitivity.

Inactive Publication Date: 2012-08-01
NANKAI UNIV
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Problems solved by technology

However, due to the adoption of the Kretschmann model and the choice of a fixed angle of incidence, the dynamic range of phase modulation detection is limited and is now reported to reach 10 -3 -10 -4 RIU【Advances in Optical Technologies 2012, ID 471957 (posted 11 June 2011, in press)】
In order to improve the dynamic range, hybrid coherent signal detection [Apolied Optics 46, 8068 (2007)] and surface plasmon enhanced ellipsometry [Sens.Actuators B114, 80 (2006)] are proposed on this basis. It solves the problem of limited dynamic range, and the sensitivity is also lower than that of Mach-Zehnder interferometry, and the running speed of ellipsometry is slow, so real-time detection cannot be realized
In 2011, Y.H.Huang proposed to use a cylindrical lens to increase the incident angle range based on the ATR (Attenuated Total Reflection) structure, thereby improving the dynamic range, but the incident angle range is 15 degrees, so the dynamic range is still limited [Opt.Let t. 36, 4092 (2011)]

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  • Differential interference phase detecting method and device of vector beam excitation surface plasma
  • Differential interference phase detecting method and device of vector beam excitation surface plasma
  • Differential interference phase detecting method and device of vector beam excitation surface plasma

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Embodiment

[0027] Such as figure 1 , figure 2 Shown: a differential interference phase detection method for surface plasmons excited by vector beams: first, the measurement sample is placed on a two-dimensional electric platform; a 30mw laser beam with a wavelength of 780nm is generated by a laser, and a 45-degree polarizer generates a line Polarized light, then enters the 1 / 4 wave plate to become circularly polarized light, and then passes through the spiral phase phase plate (SPP) and angular filter (AA) to obtain pure angular polarized light, and then passes through the two optical axes with an angle difference of 67.5 ° half-wave plate to obtain radially polarized light and angularly polarized light beams each accounting for 50%; Mismatching conditions, in the reflection imaging image, only a specific angle will appear dark ring, through Michelson interference (Michelson interference) to get the phase interference, through the interference fringes to extract the phase of the dark r...

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Abstract

The invention discloses a differential interference phase detecting method and device of a vector beam excitation surface plasma. A radially polarized beam and an azimuthally polarized beam are generated by a light source unit so as to realize high sensitivity and large dynamic range detection by using a sensing unit and a detecting unit. According to the invention, the surface plasma resonance is excited by using an axisymmetric vector beam; and high sensitivity and large dynamic range detection is realized by using differential interference phase detection.

Description

technical field [0001] The invention belongs to the technical field of optical sensing and imaging for biochemical detection, and in particular relates to a differential interference phase detection method and device for vector beam excitation of surface plasmons. Background technique [0002] Surface plasmon resonance (SPR) is a physical optical phenomenon. Since Otto and Kretschmann proposed two models of surface plasmon realization, it has attracted widespread attention and laid the foundation for the development of SPR sensing and imaging. . Utilizing the high sensitivity of SPR to small changes in the refractive index of the surrounding medium, SPR sensing has been widely used in biomedicine in the past 20 years, realizing real-time quantitative analysis of biological immune responses, with the advantages of high sensitivity and no labeling . At the same time, it also penetrates into research fields such as chemical engineering, materials, food safety, and environment...

Claims

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Application Information

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IPC IPC(8): G01N21/21G01N21/55G01N21/552
Inventor 张崇磊王蓉袁小聪
Owner NANKAI UNIV
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