Unlock instant, AI-driven research and patent intelligence for your innovation.

Method of assembling a hollow fiber bioreactor

A hollow and fiber technology, applied in the field of assembling hollow fiber bioreactors, can solve the problems of destroying bioreactors

Active Publication Date: 2012-08-15
TERUMO BCT
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If radiation is used, the high radiation doses required to modify the membrane surface may have the undesired side effect of damaging other components of the bioreactor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of assembling a hollow fiber bioreactor
  • Method of assembling a hollow fiber bioreactor
  • Method of assembling a hollow fiber bioreactor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The membranes of the present invention have a variety of geometries. Although hollow fiber membranes are shown in the figures, the method of the present invention is applicable to all forms of membranes, including flat sheet membranes. Hollow fiber membranes have been shown to be beneficial for cell proliferation in cell growth systems because in these systems the membranes allow efficient nutrient supply, waste removal and gas exchange to the cells. Also, hollow fibers provide a large surface area for cells to grow on compared to the volume of the membrane.

[0018] In the embodiment shown in the figures, cells can be grown within the lumen or intracapillary space (IC space) of the hollow fiber while the cell growth medium flows along the exterior or extracapillary space (EC space) of the hollow fiber. However, in the context of the present invention, cells can also be grown in the EC space while the cell growth medium flows in the IC space without departing from the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a method of assembling a cell growth module, and preventing the formation of cytotoxic chemicals in the cell growth module which may interfere with the growth of the cells in the cell growth module. Electromagnetic radiation such as gamma irradiation may be used to treat the membrane surface prior to the membrane being inserted into the housing. The cell growth module includes at least a membrane and a housing.

Description

field of invention [0001] The present invention relates to methods of treating membrane surfaces prior to their assembly in a bioreactor. Background of the invention [0002] There is growing interest in the use of stem cells in various medical treatments and therapies. Cell proliferation systems can be used to grow stem cells, as well as other types of cells such as bone marrow cells, which can include stem cells. Stem cells propagated from donor cells can be used to repair or replace damaged or defective tissue and are considered for the treatment of a wide range of diseases. [0003] As an important component of a cell proliferation system, a bioreactor or cell growth chamber plays an important role in providing an optimized environment for cell proliferation. Bioreactors provide efficient nutrient supply to cells and remove metabolites, as well as provide a physical and chemical environment beneficial to cell growth. [0004] Many types of bioreactors are currently av...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/12C12M3/06C12N5/00B01D67/00
CPCB01D67/009B01D71/68C12M25/10B01D2313/04B01D63/0233B01D63/031B01D71/441
Inventor F·戴尔伯格
Owner TERUMO BCT