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A kind of traditional Chinese medicine extract and preparation method for treating nephropathy

A technology of rhubarb extract and nephropathy, which is applied in the field of traditional Chinese medicine extract and its preparation for treating nephropathy, can solve the problems such as the use of rhubarb extract that has not been reported in the literature, and achieve remarkable therapeutic effect, less dosage, and simple preparation process Effect

Inactive Publication Date: 2016-03-02
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no literature report on the use of rhubarb extract for the treatment of kidney disease

Method used

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  • A kind of traditional Chinese medicine extract and preparation method for treating nephropathy
  • A kind of traditional Chinese medicine extract and preparation method for treating nephropathy
  • A kind of traditional Chinese medicine extract and preparation method for treating nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1, the extract of the present invention

[0046] (1) Take rhubarb medicinal material or decoction pieces, extract 2 times with 6 times the amount of 90% ethanol, each time for 2 hours, and filter;

[0047] (2) After the ethanol is removed from the alcohol-extracted medicinal residues, extract 2 times with 8 times the amount of water, each time for 1.5 hours, and combine the water extracts;

[0048] (3) Combine the alcohol extracts, filter, and concentrate the filtrate until there is no alcohol smell, add an appropriate amount of water to precipitate, filter to obtain precipitate A,

[0049] (4) The supernatant and the water extract are merged and filtered, and the filtrate is passed through a polyamide chromatography column, followed by elution with water of 2.5 times the volume of the resin bed and 15% ethanol of 5 times the volume of the resin bed, and finally with the volume of the resin bed 10 times the amount of 95% ethanol for elution, collect the 95% ...

Embodiment 2

[0052] Embodiment 2, the extract of the present invention

[0053] (1) Take rhubarb medicinal material or decoction pieces, extract 2 times with 4 times the amount of 60% ethanol, 1 hour each time;

[0054] (2) After the ethanol is removed from the alcohol-extracted dregs, extract 2 times with 6 times the amount of water, each time for 1 hour, and combine the water extracts;

[0055] (3) Combine the alcohol extracts, filter, and concentrate the filtrate until there is no alcohol smell, add an appropriate amount of water to precipitate, filter to obtain precipitate A,

[0056] (4) The supernatant and the water extract are combined and filtered, and the filtrate is passed through a polyamide chromatography column, followed by elution with water of 1 times the volume of the resin bed and 5% ethanol of 2 times the volume of the resin bed, and finally with the resin bed Elute with 8 times the volume of 70% ethanol, collect the 70% ethanol eluate, concentrate to a thick extract, an...

Embodiment 3

[0059] Embodiment 3, the extract of the present invention

[0060] (1) Take rhubarb medicinal material or decoction pieces, extract 3 times with 8 times the amount of 95% ethanol, each time for 3 hours;

[0061] (2) After the ethanol is removed from the dregs of alcohol extraction, extract with 10 times the amount of water for 3 times, each time for 3 hours, and combine the water extracts;

[0062] (3) Combine the alcohol extracts, filter, and concentrate the filtrate until there is no alcohol smell, add an appropriate amount of water to precipitate, filter to obtain precipitate A,

[0063] (4) The supernatant and the water extract are combined and filtered, and the filtrate is passed through a polyamide chromatography column, followed by elution with water of 5 times the volume of the resin bed and 20% ethanol of 7 times the volume of the resin bed, and finally with the resin bed Elute with 12 times the volume of 95% ethanol, collect the 95% ethanol eluate, concentrate to a ...

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Abstract

The invention discloses a traditional Chinese medicine extract for treating nephropathy and a preparation method, and belongs to the field of traditional Chinese medicine modernization. The traditional Chinese medicine extract for treating nephropathy is a rhubarb root extract which is obtained by extracting rhubarb root medicinal materials or decoction pieces. Research results of the invention show that the rhubarb root extract has good activity for the treatment of glomerulonephritis with respect to diuresis, proteinuria improvement, and hematuria improvement.

Description

technical field [0001] The invention belongs to the field of modernization of traditional Chinese medicine, relates to a new application of a traditional Chinese medicine and an extract thereof, in particular to an extract of a traditional Chinese medicine for treating nephropathy and a preparation method thereof. Background technique [0002] Rhubarb is also known as Jinbuhuan, Cattle Ear Rhubarb, Niu Xixi, etc. in the folk. It is a variety of medicinal plant roots and rhizomes in the genus Rumex of the Polygonaceae family. There are mainly sheep's trotters, batian sorrel, Nepal sorrel, etc., which are used by folks as herbal medicines. They have the effects of clearing away heat and detoxification, cooling blood to stop bleeding, killing insects and relieving itching. Rumex is rich in resources, but the research on rhubarb at home and abroad is still very scarce, and we need to further explore it. [0003] The literature summarizes the main drug effects of rhubarb as foll...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61P13/12
Inventor 夏忠庭刘景周桂荣张莉华马晓慧周水平张兰兰
Owner TIANJIN TASLY PHARMA CO LTD
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