Preparation method of atractylis lancea anti-gastric cancer active ingredient and medicinal preparation thereof
A technology of effective components and pharmaceutical preparations, which is applied in the field of extraction and pharmaceutical preparations, can solve the problems of unclear anticancer components and mechanisms of Atractylodes atractylodes, and achieve the effects of good curative effect, simple production process, and simple preparation method
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Embodiment 1
[0018] Example 1 Extraction of the effective components of Atractylodes lancea
[0019] 1) Take 20g of Atractylodes lanceolata powder as raw material, add 160 mL of distilled water, heat and reflux for 1 h, and extract the extract by centrifugal suction filtration and concentrate 1 g / mL to obtain the Atractylodes lanceolata water extract.
[0020] 2) Add the extract obtained in step 1) to an equal volume of petroleum ether, extract 3 times, and combine the petroleum ether parts. The water part obtained in the step is extracted with ethyl acetate and n-butanol in sequence according to the same method as the above petroleum ether extraction to obtain ethyl acetate part and n-butanol part.
[0021] 3) The petroleum ether part, ethyl acetate part and n-butanol part are prepared into a solution with a concentration of 0.5 mg / mL to obtain a solution of the anti-gastric cancer active component.
[0022] The anti-gastric cancer active component solution obtained in the above Example 3 was fi...
Embodiment 2
[0023] Example 2 Extraction of effective components of Atractylodes lancea
[0024] 1) Take 20g of Atractylodes lanceolata powder as raw material, add 200 mL of distilled water, heat and reflux for extraction for 2 hours, and extract the extract by centrifugal suction filtration and concentrate 1.5 g / mL to obtain the Atractylodes lanceolata water extract.
[0025] 2) Add the extract obtained in step 1) to an equal volume of petroleum ether, extract 4 times, and combine the petroleum ether parts. The water part obtained in the step is extracted with ethyl acetate and n-butanol in sequence according to the same method as the above petroleum ether extraction to obtain ethyl acetate part and n-butanol part.
[0026] 3) The petroleum ether part, ethyl acetate part and n-butanol part are prepared into a solution with a concentration of 1.0 mg / mL to obtain an anti-gastric cancer active component solution.
[0027] The anti-gastric cancer active component solution obtained in the above examp...
Embodiment 3
[0028] Example 3 Extraction of effective components of Atractylodes lancea
[0029] 1) Take 20g of Atractylodes lanceolata powder as raw material, add 240 mL of distilled water, heat and reflux for 3 hours, and extract the extract by centrifugal suction filtration and concentrate 2 g / mL to obtain the Atractylodes lanceolata water extract.
[0030] 2) Add the extract obtained in step 1) to an equal volume of petroleum ether, extract 5 times, and combine the petroleum ether parts. The water part obtained in the step is extracted with ethyl acetate and n-butanol in sequence according to the same method as the above petroleum ether extraction to obtain ethyl acetate part and n-butanol part.
[0031] 3) The petroleum ether part, ethyl acetate part and n-butanol part are prepared into a solution with a concentration of 2.0 mg / mL to obtain a solution of the anti-gastric cancer active component.
[0032] The anti-gastric cancer active component solution obtained in the above Example 3 was fi...
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