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Nutrition protective agent capable of promoting content of camptothecin in camptotheca acuminata to increase

A technology of camptothecin and protective agent is applied in the field of nutritional protective agent for promoting the content of camptothecin in camptotheca, and can solve the problems of long route, low yield, high toxicity and the like

Inactive Publication Date: 2012-09-19
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In trials in the early 1970s, camptothecin was clinically used to treat malignant tumors such as bladder cancer, gastric cancer, and leukemia, but it was highly toxic
The chemical synthesis of camptothecin started very early and has been deeply researched. There are more than ten synthetic methods, but the route is long, the yield is low, and there is no actual production value. Therefore, plant extraction is still the mainstream method of camptothecin production.

Method used

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  • Nutrition protective agent capable of promoting content of camptothecin in camptotheca acuminata to increase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 670kg of water into the 1000L reactor, then put in 36kg of urea, 36kg of magnesium sulfate, 36kg of calcium gluconate, 36kg of dipotassium hydrogen phosphate and 36kg of sodium molybdate, stir and dissolve, then slowly put in 10kg of indole acetic acid and 10kg of indole butyl Acid, 10kg naphthalene acetic acid, 10kg ethephon, 10kg kinetin, 10kg green fresh element and 10kg pectin, stir for half an hour, mix well, then add 20kg jatrorrhizine, 15kg palmitic acid and 15kg berberine, finally add 20kg Sodium glycocholate and 10kg of aspirin are stirred and mixed evenly to form the final product.

Embodiment 2

[0020] Put 470kg of water into the 1000L reactor, then put in 31kg of urea, 31kg of magnesium sulfate, 31kg of calcium gluconate, 31kg of dipotassium hydrogen phosphate, 31kg of ferrous sulfate, 31kg of boric acid, 31kg of zinc sulfate, 31kg of manganese sulfate, 31kg of copper sulfate and 31kg of Sodium molybdate, stir and dissolve, then slowly add 10kg gibberellin, 10kg cytokinin, 10kg paclobutrazol, 10kg indole acetic acid, 10 kg indole butyric acid, 10 kg naphthalene acetic acid, 10 kg ethephon, 10 kg kinetin, 10 kg green fresh Stir for half an hour and mix well, then add 20kg of Cathone, 20kg of citric acid and 30kg of berberine, and finally add 10kg of benzalkonium bromide, 10kg of salicylic acid, 10kg of sodium glycocholate and 20kg of aspirin , Stir and mix evenly to form the final product.

Embodiment 3

[0022] Put 620kg water into the 1000L reactor, then put 20kg dipotassium hydrogen phosphate, 20kg ferrous sulfate, 20kg boric acid, 20kg zinc sulfate, 20kg ammonium molybdate, 50kg manganese sulfate, 25kg copper sulfate and 25kg sodium molybdate, stir and dissolve Then slowly put in 20kg gibberellin, 10kg cytokinin, 10kg paclobutrazol, 10kg ethephon, 10kg kinetin, 10kg penicillin and 10kg whole sexin, stir for half an hour, mix evenly, then add 15kg Casson, 15kg lemon acid, 15kg jatrorrhizine and 15kg palmitic acid, finally add 20kg benzalkonium bromide, 10kg salicylic acid and 10kg sodium glycocholate, stir and mix evenly to form the final product.

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Abstract

The invention discloses a nutrition protective agent capable of promoting content of camptothecin in camptotheca acuminata to increase, and belongs to the technical field of nutrition of trees. The nutrition protective agent is characterized by comprising the following substances in percentage by weight: 13 to 37 percent of nutritional ingredient, 4 to 13 percent of growth hormone, 2 to 9 percent of preservative, 1 to 7 percent of synergistic agent and 43 to 71 percent of water. The nutrition protective agent capable of promoting the content of the camptothecin in the camptotheca acuminata to increase has various effects of promoting the content of the camptothecin in camptotheca acuminata fruits, camptotheca acuminata leaves and camptotheca acuminata branches to increase, the camptotheca acuminata to grow new roots and branches, the nursery stock and the branches of the camptotheca acuminata to extend and thicken and the camptotheca acuminata fruits to increase, can effectively prevent various diseases and pests of the trees and has a special effect of promoting the content of the camptothecin in the camptotheca acuminata to increase. The nutrition protective agent is easy and convenient to process, low in equipment investment and low in production cost, can be safely stored, transported and used and cannot pollute the environment, sources of raw materials are ensured, and the energy consumption is reduced.

Description

technical field [0001] The invention belongs to the technical field of tree nutrition, and specifically relates to a nutritional protection agent capable of promoting the content of camptothecin in camptothecin. Background technique [0002] Campylodendron is a fast-growing woody plant, and it is a unique tree species in my country, belonging to the blue fruit tree family. Camptothecin is an alkaloid in camptothecin. It is an active substance extracted from the bark and fruit of the Chinese crude drug camptothecin by Monroe E. Wall of the National Cancer Institute of the United States. It is a pyrroloquinoline alkaloid camptothecin. It is quite effective for various animal tumors, especially for tumors resistant to multiple drugs. In trials in the early 1970s, camptothecin was clinically used to treat malignant tumors such as bladder cancer, gastric cancer, and leukemia, but it was highly toxic. So far, the development and research on camptothecin has made breakthroughs in...

Claims

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Application Information

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IPC IPC(8): C05G3/00
Inventor 毛胜凤陈安良童森淼
Owner ZHEJIANG FORESTRY UNIVERSITY
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