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Application of Jaceosidin in preparation of medicine for preventing and treating insulin resistance, nonalcoholic fatty liver diseases and other diseases related to II-type diabetes mellitus

A technology of insulin resistance and palm cyanidin, which is applied in the direction of metabolic diseases, drug combination, pharmaceutical formula, etc., can solve the problems of little research and achieve the effect of reducing lipid droplet vacuoles, reducing the degree of fat lesions, and reducing the content

Inactive Publication Date: 2012-10-03
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Since the chemical structure of cyanidin (Jaceosidin) was reported, there has been little research on this compound, and its pharmacological activity, especially in the treatment of type II diabetes related to insulin resistance and non-alcoholic fatty liver related diseases. effects, etc., have not been reported so far

Method used

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  • Application of Jaceosidin in preparation of medicine for preventing and treating insulin resistance, nonalcoholic fatty liver diseases and other diseases related to II-type diabetes mellitus
  • Application of Jaceosidin in preparation of medicine for preventing and treating insulin resistance, nonalcoholic fatty liver diseases and other diseases related to II-type diabetes mellitus
  • Application of Jaceosidin in preparation of medicine for preventing and treating insulin resistance, nonalcoholic fatty liver diseases and other diseases related to II-type diabetes mellitus

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Experimental program
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Effect test

Embodiment 1

[0040] 1. Pharmacological experiment of palm cyanidin

[0041] High-fat diet-induced mouse insulin resistance type II diabetes model and non-alcoholic fatty liver model [1，2]

[0042] BALB / c male mice, 6-8 weeks old, weighing 18-22 grams, were raised in an SPF grade animal room at 21±2°C, with free access to water and food, and alternated day and night for 12 hours. They were randomly divided into two groups, the normal control group (normal chow diet, NCD) was fed with normal diet, and the high fat model group (high fat diet, HFD) was fed with high fat diet (60kcal%Fat).

[0043] After feeding for 16 weeks, the high-fat model group was randomly divided into 4 groups, and 3 groups were given intraperitoneal injection of palm cyanidin 2mg / kg, 4mg / kg and pioglitatone (Pioglitatone) 4mg / kg respectively according to 0.1ml / 20g body weight. , the model group and the normal group were given the same amount of PBS for 14 consecutive days.

[0044] Afterwards, the basal blood glucos...

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Abstract

The invention belongs to the technical field of pharmaceutics. According to the invention, Jaceosidin can be used for remarkably improving mouse insulin resistance induced by high-fat diets, further improving mouse symptoms of the II-type diabetes mellitus models and remarkably improving the nonalcoholic fatty liver diseases and the chronic liver injury caused by the high-fat diets. The Jaceosidin serves as a novel medicine for treating insulin resistance, has activities of controlling blood glucose and improving insulin sensitivity and the like well, meanwhile, can be used for treating the nonalcoholic fatty liver diseases and is capable of effectively reducing liver fat pathological changes and chronic liver injury. Therefore, the Jaceosidin can be used for treating the insulin resistance, the nonalcoholic fatty liver diseases and the diseases related to II-type diabetes mellitus and preparing corresponding therapeutic medicines.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmacy and belongs to the patent of medicine use. 2. Background technology [0002] Since the chemical structure of cyanidin (Jaceosidin) was reported, there has been little research on this compound, and its pharmacological activity, especially in the treatment of type II diabetes related to insulin resistance and non-alcoholic fatty liver related diseases. effects, etc., have not been reported so far. The present invention mainly finds that palm cyanidin can significantly improve insulin resistance, type II diabetes and non-alcoholic fatty liver models. [0003] Brown cyanidin (Jaceosidin), its structural formula is as follows: [0004] 3. Contents of the invention [0005] The purpose of the present invention is to study the application of palm cyanidin in the prevention and treatment of insulin resistance, non-alcoholic fatty liver and other related diseases of type II diabetes. [0006] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P3/10A61P1/16
Inventor 徐强孙洋张琦李万帅吴雪丰龚方苑尹业
Owner NANJING UNIV
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