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External application drug composition for treating fungus infection of skin

A technology of topical medicine and skin fungus, which is applied in the field of medicine, can solve problems affecting the quality of life of patients, and achieve the effects of relieving skin burning sensation, shortening the anti-itching time, and enhancing antifungal activity

Active Publication Date: 2012-10-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, since terbinafine hydrochloride and butenafine hydrochloride fundamentally treat local skin fungal infections by killing or inhibiting fungi, this will inevitably relieve symptoms such as local skin itching, skin flushing or redness, especially pruritus symptoms take a long time
Therefore, when the patient's itching is unbearable, the itching cannot be relieved quickly, which affects the quality of life of the patient to a certain extent.

Method used

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  • External application drug composition for treating fungus infection of skin
  • External application drug composition for treating fungus infection of skin
  • External application drug composition for treating fungus infection of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Gel

[0057]

[0058] Preparation process: Dissolve butenafine hydrochloride, miconazole nitrate and loratadine in 1,2-propanediol, then add appropriate amount of distilled water and glycerol, and then combine carbopol 940 with polysorbate-80 Mix well with 300ml of distilled water, dissolve sodium hydroxide in 100ml of distilled water, add the upper liquid and stir well, then dissolve ethyl paraben in ethanol and then gradually add and stir to obtain a transparent gel.

Embodiment 2

[0059] Example 2 Gel

[0060]

[0061] Triethanolamine adjusts PH value to 6.0

[0062] Preparation process: Dissolve butenafine hydrochloride and cetirizine hydrochloride in 1,2-propanediol, then add appropriate amount of distilled water and glycerol, and then combine Carbopol 940 with polysorbate-80 and 300ml of distilled water Mix well, adjust the pH value of triethanolamine to 6.0, then dissolve ethyl paraben in ethanol and gradually add and stir, add distilled water to 1000g to obtain a transparent gel.

Embodiment 3

[0063] Example 3 Gel

[0064]

[0065] Triethanolamine adjusts PH value to 7.0

[0066] The preparation process is the same as in Example 2.

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Abstract

In the prior art, squalene cyclooxygenase inhibitors provide unobvious itching relieving effects for treatment of fungus infection. In order to over the disadvantage of the squalene cyclooxygenase inhibitors, the present invention provides an external application drug composition containing a squalene cyclooxygenase inhibitor and an H1 receptor blocker, wherein the drug composition has characteristics of fungus killing, synergistic anti-inflammatory and synergistic itching relieving, and symptoms of fungus infection of superficial skin can be significantly improved with the drug composition.

Description

[0001] This application is a divisional application of the patent application with the application number 200910211355.4 and the invention title of "A pharmaceutical composition for the treatment of fungal skin infections" filed on October 31, 2009. Technical field [0002] The invention belongs to the field of medicine, and specifically relates to a pharmaceutical composition for external use for treating skin fungal infections. Background technique [0003] Superficial skin fungal infections occupies a high proportion of skin diseases. They are generally easy to relapse and difficult to cure. They are one of the intractable skin diseases. Clinically common skin fungal infectious diseases include tinea hand, tinea pedis, tinea cruris, tinea corporis, and tinea capitis. The symptoms are mainly manifested in local skin moist flushing, erosion, whitening or small blisters, unbearable skin itching, erysipelas and lymphangitis often caused by secondary infection after scratching, and ...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K31/137A61K31/495A61K31/445A61K31/496A61K31/4174A61K31/4196A61P31/10A61P17/00A61P17/04A61P29/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION