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Cinnamic acid derivative crystal and preparation method thereof

A technology of cinnamic acid derivatives and crystals, applied in the field of cinnamic acid derivative crystals and their preparation

Inactive Publication Date: 2012-10-24
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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No synthesis of the two has been reported in the previous synthesis

Method used

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  • Cinnamic acid derivative crystal and preparation method thereof
  • Cinnamic acid derivative crystal and preparation method thereof
  • Cinnamic acid derivative crystal and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Preparation of Crystals of Dimethoxycinnamic Nickel Salt and Ethylenediamine

[0022] Take a 50ml flask and add 25ml of absolute ethanol. Weigh 1.04g (5mmol) veratraldehyde and 0.62g (>5mmol) malonic acid, and place them in a flask. Under the catalysis of pyridine, the volume of pyridine is 1 / 10 of the volume of the previous solutions, heated and stirred at 80° C. for 10 h. After the reaction, a crude product was obtained. After the crude product was filtered out by suction, it was pickled with dilute hydrochloric acid, then washed with NaOH alkali, and finally concentrated hydrochloric acid was added dropwise to precipitate out, and compound 1 was obtained by suction filtration and drying, with a yield of 70%.

[0023] Take 0.526 (2mmol) of NiSO 4 .7H 2 0, configured as solution 1, take 0.832 (4 mmol) of dimethoxycinnamic acid and slowly add NaOH solution to it until it dissolves (pH 7.5)

[0024] Configured as solution 2. Pour solution 1 into solution 2, stir an...

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Abstract

The invention relates to a cinnamic acid derivative crystal and a preparation method thereof, which belong to the technical field of bio-pharmaceuticals. The cinnamic acid derivative crystal is characterized by being a nickel crystal of trans-3,4-dimethoxy benzene olefine acid, and is shown in the specifications. The cinnamic acid derivative crystal prepared with the method has urease antagonism. The cinnamic acid derivative crystal can be applied to preparation of a medicament for treating diseases caused by helicobacter pylori.

Description

technical field [0001] The invention relates to a cinnamic acid derivative crystal and a preparation method thereof, belonging to the field of biopharmaceuticals. Background technique [0002] Since cisplatin was used in the clinical treatment of cancer in 1969 and achieved good curative effect, metal complexes have received widespread attention in recent years. Mononuclear or binuclear complexes have antibacterial, anticancer and antiviral biological activities. Multinuclear complexes have attracted increasing attention due to their important roles in catalysis, magnetic materials, semiconductors and bioinorganic chemistry. Nickel is a common transition metal, not only in organisms, but also in plants. It has particularly important biological activity. Cinnamic acid, namely 3-phenylacrylic acid, is the active ingredient of the traditional Chinese medicine cinnamon. In vitro experiments show that it and its derivatives have anti-tumor, anti-bacterial, anti-inflammatory effe...

Claims

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Application Information

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IPC IPC(8): C07F15/04A61P31/04
Inventor 朱海亮朱慧钱绍松杨钟鸣孙娟
Owner SHANDONG UNIV OF TECH
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