Purification method of esomeprazole

A technology of esomeprazole and esomeprazole potassium salt, which is applied in the field of purification of esomeprazole, and can solve problems such as difficult control of the oxidation process
CN102757421AInactive Publication Date: 2012-10-31CHIA TAI TIANQING PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHIA TAI TIANQING PHARMA GRP CO LTD
Publication Date
2012-10-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a purification method of esomeprazole. According to the purification method, esomeprazole or salt thereof to be purified is transformed into potassium esomeprazole and then separated by crystallization, and if necessary, the crystallization product is transformed into esomeprazole or salt thereof. Compared with the conventional recrystallization method, the purification method can purify esomeprazole with high efficiency to obtain high-purity esomeprazole or salt thereof. The purification method is particularly suitable for purification of drug compounds with extremely strict requirements on the purity.
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Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a method for purifying esomeprazole. Background technique

[0002] Esomeprazole (S)-omeprazole, chemical name: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl Base-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole can effectively inhibit gastric acid secretion and is often used to treat diseases related to gastric acid secretion disorders, such as gastric ulcer and duodenal ulcer. This compound has the following structural formula:

[0003]

[0004] In the prior art, esomeprazole is usually prepared by oxidative resolution or asymmetric oxidation of thioether. Since the oxidation process is difficult to control, the formation of various by-products cannot be avoided. For example, when thioether is oxidized to sulfoxide It is further oxidized to sulfone. Contents of the invention

[0005] The object of the present invention is to provide a kind of purification method of esomeprazole, ...

Claims

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