Application of tree peony bark to preparation of synergistic agent product for antifungal medicine

An antifungal drug, the technology of Moutan Cortex, which is applied in the field of medicine, can solve the problems such as no reports of Moutan Cortex, achieve good clinical application prospects, improve antifungal effect, and enhance the effect of inhibition

Inactive Publication Date: 2014-08-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is no report on the combined use of Cortex Moutan as an antifungal drug synergist and antifungal drugs to treat fungal diseases

Method used

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  • Application of tree peony bark to preparation of synergistic agent product for antifungal medicine
  • Application of tree peony bark to preparation of synergistic agent product for antifungal medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Cortex Moutan used alone, cortex Moutan and fluconazole in combination on the effect of different clinical fungal strains Materials and methods

[0017] 1. Test drug:

[0018] The medicinal raw material of Moutan Cortex is the dried root bark of the Ranunculaceae plant Moutan. Extraction process: Add the crushed medicinal material powder into a 1000ml round bottom flask, add 70% ethanol in a water bath and reflux for 2 hours, filter the reflux liquid, put it into a weighed flask, and rotate it under reduced pressure at about 50°C until it becomes a viscous extract. . Add distilled water into the flask, heat to fully dissolve (take a little as the water extract to obtain a crude drug concentration of 1g / ml), then add an amount of absolute ethanol equal to that of distilled water, heat and mix thoroughly, and combine the extracts and mix to obtain Take a little of the crude drug concentration of 0.5g / ml into EP tubes for in vitro experiments.

[0019] Flucon...

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Abstract

The invention relates to the technical field of medicines, in particular to application of tree peony bark to the preparation of a synergistic agent product for an antifungal medicine. The tree peony bark is the dried root bark of ranunculaceae plant peony (namely Paeonia suffruticosa Andr.) in 'Sheng Nong's herbal classic', and has a medicinal history of more than 2,000 years. In-vitro cell tests show that the tree peony bark has an inhibitory activity on various clinically separated candida albicans; when jointly used with a fluconazole antifungal agent, a tree peony bark extract can improve a therapeutic effect on superficial fungal infection and deep fungal infection to varying degrees and can recover an effect of the antifungal medicine on medicine-resistant fungi. Thus, the tree peony bark can be used as the synergistic agent for the antifungal medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of Cortex Moutan for preparing synergist products of antifungal drugs. Background technique [0002] Cortex Moutan is the dried root bark of Paeonia suffruticosa Andr., a plant in the Ranunculaceae family. It was first recorded in "Shen Nong's Materia Medica" and listed as a middle grade. It has a medicinal history of more than 2,000 years. Slightly cold in nature, bitter and pungent in taste, it has the effects of clearing away heat and cooling blood, promoting blood circulation and removing stasis. Modern pharmacological research shows that Moutan Cortex has the functions of regulating cardiovascular system, anti-convulsion, protecting liver, regulating urinary system, regulating immune cells, antibacterial and anti-inflammatory function etc. [0003] However, there is no report on the combined use of Cortex Moutan as a synergist of antifungal drugs and antifungal dru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P31/10A61K125/00
Inventor 阎澜熊娟鹿辉曹永兵姜远英
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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