2-sulfo-4-amino-1-naphthol derivative and preparation method and application thereof

A technology of naphthol derivatives and derivatives, applied in drug combinations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., can solve the problems of tumors' low dependence on angiogenesis, drug resistance, adverse reactions, etc.
CN102766103AInactive Publication Date: 2012-11-07QILU PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QILU PHARMA
Publication Date
2012-11-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of pharmaceutical chemicals, and in particular relates to a 2-sulfo-4-amino-1-naphthol derivative and pharmaceutically acceptable salt thereof, a solvate of the derivative, and a solvate of the pharmaceutically acceptable salt. The invention also relates to a preparation method, a medical composition and application of the 2-sulfo-4-amino-1-naphthol derivative. The 2-sulfo-4-amino-1-naphthol derivative has a good tyrosine kinase inhibiting effect and low toxicity and has great significance for the clinical treatment of tumor.
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Description

technical field

[0001] The invention belongs to the field of medicine and chemical industry, and specifically relates to a class of 2-thio-4-amino-1-naphthol derivatives, pharmaceutically acceptable salts thereof, solvates of the derivatives and the pharmaceutically acceptable Solvates of accepted salts. The present invention also relates to the preparation method of the 2-thio-4-amino-1-naphthol derivative, its pharmaceutical composition and the use of the derivative. Background technique

[0002] Tumor is one of the main diseases that seriously threaten human life and health. According to the statistics of the World Health Organization, about 6.9 million patients die of tumors all over the world every year. Due to changes in living environment and living habits, under the influence of adverse environment and some unfavorable factors, the incidence and mortality of tumors have gradually increased in recent years.

[0003] In the past, the treatment of tumors was achieved ...

Claims

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