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Harmful particle detection method before clinical use of injection

A detection method and injection technology, which are used in measurement devices, particle size analysis, particle and sedimentation analysis, etc., can solve problems such as low efficiency, difficulty in guaranteeing the single value of test results, and inability to obtain test results.

Inactive Publication Date: 2012-11-28
SHAOXING UNIVERSITY
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Problems solved by technology

Therefore, in this type of detection method, the ultrasonic emission probe must be fixed on the outer wall of the measured object, so it is impossible to detect the particle size falling in the near-field area of ​​the sound pressure; some scholars also propose to pass the liquid to be tested through a special ultrasonic probe A thin tube is used to detect the particle size and ensure a single particle at a time, but this method is inefficient and requires modification of the measured object and container, and cannot be non-invasive and non-destructive for detection objects such as bottled injections sexual detection
In addition, considering that the relationship curve between the size factor ka and the backscattering sound pressure is non-monotonic, in the case of constant ultrasonic emission frequency, it is difficult to guarantee the uniqueness of the detection results, and accurate detection results cannot be obtained

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  • Harmful particle detection method before clinical use of injection
  • Harmful particle detection method before clinical use of injection
  • Harmful particle detection method before clinical use of injection

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Embodiment Construction

[0041] The implementation of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0042] The invention relates to a method for detecting harmful particles of injections before use, which includes a preliminary preparation step, a water intake and drainage step, a detection preparation step and a detection step.

[0043] Among them, the preparatory step refers to fixing the infusion bottle 1 to be tested and the comparison infusion bottle 2 on the respective infusion bottle brackets and the clamping mechanism 10 respectively. The infusion bottle to be tested contains a certain volume of injection A and may contain For other harmful particles, the comparison infusion bottle 2 contains the same volume of comparison solution composed of pure injection A and evenly distributed 50 μm glass microsphere particles, and the point ultrasonic receiving transducer 3 is fixed on the bottom of the comparison infusion bottle 2 The in...

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Abstract

The invention discloses a harmful particle detection method before clinical use of an injection. The harmful particle detection method comprises an early-stage preparation step, a water feeding and draining step, a preparation detecting step and a detection step. The detection step comprises the following specific steps: controlling an ultrasonic transducer and a detection ultrasonic transducer to respectively transmit pulse ultrasonic waves according to the reference frequency f0, the frequency of 1.5f0 and the frequency of 0.75f0 by using a microprocessor, respectively recording the three scattering echo measuring values and overlapping the three scattering echo measuring values to obtain comparison scattering sound pressure V0 and scattering sound pressure V1 to be detected; obtaining a harmful particle detection result of information of particle sizes in relevant detection regions are longer or shorter relative to standard particles with 50 Mum particle size each and the like according to a ratio, namely k*V1 / V0 by the microprocessor; and meanwhile, displaying the result through a touch screen and carrying out sound-light alarming. According to the technical scheme, due to the adoption of a triple media ultrasonic back scattering and centrifugal sedimentation technology, harmful particle detection with non contact, non intrusion, non destructiveness and measurement error correcting function can be realized, and is simple in operation and feasibility.

Description

technical field [0001] The invention relates to a detection method related to medical injections, in particular to a method for detecting harmful particles of injections before use. Background technique [0002] Harmful particles referred to in the present invention refer to insoluble particles that exist in injections and can be observed visually under specified conditions, and their particle size or length is usually >50 μm. A large number of studies have proved that harmful particles can cause potentially serious harm, such as inflammatory reactions, granulomas, tumors, pyrogen-like reactions, etc. Larger or too many particles in the infusion will cause local blood vessel blockage and thrombus, resulting in insufficient blood supply or edema or phlebitis due to hypoxia. The 2010 edition of "Chinese Pharmacopoeia" stipulates that for insoluble particles contained in injections, those with a diameter of 50 μm or more must be detected. If there is a convenient and quick...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/02G01N15/02
Inventor 张华芳
Owner SHAOXING UNIVERSITY
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