Injectable and degradable bone cement, and preparation method and application thereof

A kind of bone cement and borate technology, applied in medical science, prosthesis and other directions, can solve the problems of surrounding tissue and spinal cord injury, lack of osteoinductive effect, poor biodegradability, etc., to achieve excellent biological activity and biocompatibility, The effect of promoting the proliferation and differentiation of osteoblasts and promoting the growth of new bone
CN102813962BActive Publication Date: 2014-08-13TONGJI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TONGJI UNIV
Publication Date
2014-08-13

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Abstract

The invention relates to a bone cement, and a preparation method and application thereof, belonging to the technical field of biomaterials. The bone cement is prepared from the following components expressed in weight percentage: 50 to 80% of solid phase borate bioglass powder and 20 to 50% of modified liquid phase chitosan sol liquid. Compared with conventional bone cement, the bone cement provided by the invention has the advantages of biodegradability, excellent bone conduction, bone induction, osseointegration performance and ossification performance during degradation and capacity of forming bone tissue at last. The preparation method for the bone cement has the advantages of a simple process, simple equipment, easy operation and low cost; the bone cement is injectable and can realize minimally invasive, even noninvasive, treatment; the method can be used for preparing a bone filler and a carrier material for orthopaedic drugs; and the bone cement is applied in bone formation and regeneration in bone tissue engineering or in treatment of orthopaedic diseases.
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Description

technical field

[0001] The invention belongs to the technical field of biomaterials, and relates to a bone cement and its preparation method and application. Background technique

[0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of powder and monomer. It can be cured by mixing it in a certain proportion at room temperature, and it can be placed on the replacement joint or filling site After the reaction is over, the joint can be fixed or the bone defect can be repaired.

[0003] Since the advent of bone cement in the early 1960s, the main bone cement research contents include bioceramics, polymethyl methacrylate (PMMA) bone cement, calcium phosphate, and hydroxyapatite bone cement.

[0004] Calcium phosphate and hydroxyapatite bone cement are representative of biologically active bone cement. Their chemical composition is very similar to the main components of human bone tissue. They have good biocompatibility, goo...

Claims

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