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Injectable and degradable bone cement, and preparation method and application thereof

A kind of bone cement and borate technology, applied in medical science, prosthesis and other directions, can solve the problems of surrounding tissue and spinal cord injury, lack of osteoinductive effect, poor biodegradability, etc., to achieve excellent biological activity and biocompatibility, The effect of promoting the proliferation and differentiation of osteoblasts and promoting the growth of new bone

Active Publication Date: 2014-08-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, apatite material has poor biodegradability and lacks osteoinductive effect
[0005] Although the traditional polymethylmethacrylate (PMMA) bone cement has certain biocompatibility and high mechanical strength, it cannot directly induce the growth of bone tissue, and the interface binding force between the bone and the host is low. Easy to loosen, leading to implant failure; and PMMA bone cement forms too high heat accumulation temperature during curing, which can easily cause damage to surrounding tissues and spinal cord

Method used

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  • Injectable and degradable bone cement, and preparation method and application thereof
  • Injectable and degradable bone cement, and preparation method and application thereof
  • Injectable and degradable bone cement, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] (1) Preparation of solid phase borate glass powder:

[0076] According to the composition of borate bioglass in Table 1, weigh the raw materials of each component, mix them evenly, put the original ingredients in a platinum crucible in a silicon-molybdenum furnace at 1100-1150°C, melt for 4 hours, and take out the obtained clarified glass The liquid is poured on the preheated steel plate to obtain a glass block. The obtained glass block is further crushed and classified by various crushing equipment, and the powder with a particle diameter of 30-40 μm is selected for use.

[0077] Table 1

[0078]

[0079] The last line of numbers in Table 1 is the mole percentage of each substance in the borate glass frit (the same as in the following table).

[0080] (2) Preparation of liquid-phase modified chitosan mixed sol:

[0081] Prepare the bone cement liquid phase with the following mass percentages of components: 2% acetic acid, 1% chitosan, 6% disodium β-glycerophospha...

Embodiment 2

[0085] (1) According to the borate bioglass composition in Table 2, weigh the raw materials of each component to prepare the original ingredients. After mixing evenly, put the original ingredients in a platinum crucible in a silicon-molybdenum furnace at 1100-1150 ° C for 4 hours. After taking it out, pour the resulting clarified glass liquid on the preheated steel plate to obtain a glass block. The obtained glass block is further crushed and classified by various crushing equipment, and the powder with a particle diameter of 30-40 μm is selected for use.

[0086] Table 2

[0087]

[0088]

[0089] (2) Prepare the bone cement liquid phase with the following mass percentages of components: 3% acetic acid, 2% chitosan, 7% disodium β-glycerophosphate, and 88% deionized water. Mix 3 g of glacial acetic acid with 88 g of deionized water to prepare an acetic acid solution. Finally, 2 g of chitosan (98% deacetylated) was weighed and dissolved in the prepared acetic acid solut...

Embodiment 3

[0094] (1) According to the composition of borate bioglass in Table 3, weigh the raw materials of each component to prepare the original ingredients. After mixing evenly, put the original ingredients in a platinum crucible in a silicon-molybdenum furnace at 1100-1150 ° C for 4 hours. After taking it out, pour the resulting clarified glass liquid on the preheated steel plate to obtain a glass block. The obtained glass block is further crushed and classified by various crushing equipment, and the powder with a particle diameter of 30-40 μm is selected for use.

[0095] table 3

[0096]

[0097] (2) Prepare the bone cement liquid phase with the following mass percentages of components: 4% acetic acid, 3% chitosan, 9% disodium β-glycerophosphate, and 84% deionized water. Mix 4 g of glacial acetic acid with 84 g of deionized water to prepare an acetic acid solution. Finally, 3g of chitosan (98% deacetylated) was weighed and dissolved in the prepared acetic acid solution, and m...

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Abstract

The invention relates to a bone cement, and a preparation method and application thereof, belonging to the technical field of biomaterials. The bone cement is prepared from the following components expressed in weight percentage: 50 to 80% of solid phase borate bioglass powder and 20 to 50% of modified liquid phase chitosan sol liquid. Compared with conventional bone cement, the bone cement provided by the invention has the advantages of biodegradability, excellent bone conduction, bone induction, osseointegration performance and ossification performance during degradation and capacity of forming bone tissue at last. The preparation method for the bone cement has the advantages of a simple process, simple equipment, easy operation and low cost; the bone cement is injectable and can realize minimally invasive, even noninvasive, treatment; the method can be used for preparing a bone filler and a carrier material for orthopaedic drugs; and the bone cement is applied in bone formation and regeneration in bone tissue engineering or in treatment of orthopaedic diseases.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and relates to a bone cement and its preparation method and application. Background technique [0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of powder and monomer. It can be cured by mixing it in a certain proportion at room temperature, and it can be placed on the replacement joint or filling site After the reaction is over, the joint can be fixed or the bone defect can be repaired. [0003] Since the advent of bone cement in the early 1960s, the main bone cement research contents include bioceramics, polymethyl methacrylate (PMMA) bone cement, calcium phosphate, and hydroxyapatite bone cement. [0004] Calcium phosphate and hydroxyapatite bone cement are representative of biologically active bone cement. Their chemical composition is very similar to the main components of human bone tissue. They have good biocompatibility, goo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/10A61L27/50
Inventor 黄文旵崔旭周萘李乐王德平
Owner TONGJI UNIV
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