High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide

A technology of astragalus polysaccharide and composition, which is applied in the field of pharmaceutical compositions containing astragalus polysaccharide, can solve the problems of low yield and biological activity of astragalus polysaccharide, high requirements on method, equipment and environment, unfavorable promotion, development and application, etc. Conducive to continuous operation, beneficial to large-scale production use, the effect of improving productivity and biological activity

Active Publication Date: 2012-12-12
BEIJING CENT BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many reports involving the extraction and separation of astragalus polysaccharides, the method equipment and environmental requirements are very high, the method is relatively complicated, and the cost is high, which is not conducive to promotion, development and application.
However, the traditional astragalus polysaccharide separation and extraction process mostly adopts the simple "water extraction and alcohol precipitation method". lower

Method used

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  • High-activity astragalus polysaccharide and preparation method of pharmaceutical composition of high-activity astragalus polysaccharide

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Experimental program
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Effect test

Embodiment 1

[0035]Weigh 10g of Radix Astragali, crush it into a coarse powder with a diameter of 300 μm, add 10 times the amount of 1% CaO aqueous solution and soak for 60 minutes; ultrasonically extract 3 times (power 60Kw, temperature 60°C), 30 minutes each time, combine the extracts, and quickly cool to At room temperature, centrifuge at 12000rpm, the centrifugate passes through a 0.22μm microporous membrane, the pressure of the membrane is 0.3MPa, the membrane is continuously washed with warm water, the amount of water added is 3 times that of the astragalus polysaccharide centrifugate, and the filtrate passes through the molecular weight cut-off It is a 200,000 Dalton ultrafiltration membrane, and the ultrafiltrate is then concentrated through a reverse osmosis membrane at a pressure of 10MPa (collecting the outflowing water and returning to the extraction tank for reuse), and then spray-dried (the inlet air temperature of spray drying is 160°C , the air outlet temperature is 80° C., ...

Embodiment 2

[0037] Weigh 5 g of Radix Astragali, crush it into a coarse powder with a diameter of 200 μm, add 8 times the amount of 1% CaO aqueous solution and soak for 30 min; ultrasonically extract twice (power 20Kw, temperature 40°C), each time for 60 min, combine the extracts, and quickly cool to Centrifuge at room temperature at 10000rpm, the centrifugate passes through a 0.45μm microporous membrane, the pressure of the membrane is 0.2MPa, the membrane is continuously washed with warm water, the amount of water added is twice that of the astragalus polysaccharide centrifugate, and the filtrate passes through the molecular weight cut-off It is an ultrafiltration membrane of 100,000 Daltons, and the ultrafiltrate is then concentrated through a reverse osmosis membrane at a pressure of 15 MPa (collecting the outflowing water, returning to the extraction tank for reuse), and spray drying (the inlet air temperature of the spray drying is 180°C , the air outlet temperature is 90° C., and th...

Embodiment 3

[0039] Weigh 20g of Astragalus medicinal decoction pieces, crush them into a coarse powder with a diameter of 500μm, add 5 times the amount of 1% CaO aqueous solution and soak for 40min; ultrasonically extract once (power 40Kw, temperature 80°C), each time for 90min, combine the extracts, and cool rapidly to room temperature, centrifuged at 8000rpm, the centrifugate passed through a 0.75μm microporous membrane, the pressure of the membrane was 0.1MPa, the membrane was continuously washed with warm water, and the amount of water added was 1 times that of the astragalus polysaccharide centrifugate, and the filtrate was cut off Ultrafiltration membrane with a molecular weight of 50,000 Daltons, and the ultrafiltrate is then concentrated through a reverse osmosis membrane at a pressure of 20 MPa (collecting the outflowing water, returning to the extraction tank for reuse), and spray-dried (the inlet air temperature for spray drying is 140 °C, the air outlet temperature is 70 °C, an...

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Abstract

The invention discloses a preparation method of high-activity astragalus polysaccharide. Further, the invention relates to an astragalus polysaccharide containing pharmaceutical composition prepared from the astragalus polysaccharide. A preparation method of the astragalus polysaccharide comprises the following steps of: crushing Radix Astragali medicinal material, immersing it into a CaO aqueous solution, and successively carrying out ultrasonic extraction, cryoprecipitation, centrifugation, microfiltration, ultrafiltration, reverse osmosis and spray drying to obtain the astragalus polysaccharide. The extracted astragalus polysaccharide provided by the invention has high activity and high yield. In addition, the preparation method has a simple technology, is time-saving, energy-saving, highly efficient and simple, and is easy for popularization, development and application.

Description

technical field [0001] The invention belongs to the field of natural medicines, and relates to a method for separating and preparing highly active astragalus polysaccharide from the traditional Chinese medicine astragalus, and further relates to a method for preparing the astragalus polysaccharide separated and prepared in the present invention into a pharmaceutical composition containing astragalus polysaccharide. Background technique [0002] Astragalus membranaceus is one of the important varieties of Chinese medicinal materials in my country. Its medicinal part is the root, which has the functions of invigorating qi and raising yang, solidifying the surface and stopping sweating, diuresis and detumescence, promoting body fluid and nourishing blood, clearing stagnation and numbness, detoxifying and discharging pus, and suppressing sores. It is the main ingredient of many traditional Chinese medicine compound prescriptions, patent medicines and health care products. Accordi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P37/04
Inventor 王心喜李学良王秀敏江厚生
Owner BEIJING CENT BIOLOGY
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