Vitamin C effervescent granule and preparation method thereof

A technology of effervescent granules and vitamins, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of disintegration timeout, poor stability, and disintegration time easily affected by water temperature, etc. problems, to achieve the effect of increasing disintegration speed, improving stability, and facilitating storage and transportation

Active Publication Date: 2012-12-19
SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current vitamin C effervescent granules often have the problems of being relatively dispersed in water, often sinking at the bottom of the cup, and disintegrating over time, and the disintegration time is easily affected by th

Method used

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  • Vitamin C effervescent granule and preparation method thereof
  • Vitamin C effervescent granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Acid Granules Recipe:

[0015] Vitamin C (40-60 mesh crystal) 150g; tartaric acid (40-60 mesh crystal) 1050g; sunset yellow 1g.

[0016] Alkali grain formula:

[0017] Sodium bicarbonate 1200g; Sodium chloride 30g; Sucrose 400g; Aspartame 50g; Sunset yellow 10g; Hydroxypropyl methylcellulose 5g.

[0018] Preparation process: Acid granules: Dissolve the prescribed amount of sunset yellow in an appropriate amount of 80% ethanol aqueous solution by ultrasonic to obtain an ethanol aqueous solution containing pigment. After mixing vitamin C and tartaric acid evenly according to the prescription amount, the soft material is prepared with the prepared ethanol aqueous solution containing pigment, granulated with a 24-mesh sieve, dried at 50°C, and sieved through a 16-mesh sieve and a 60-mesh sieve respectively.

[0019] Alkali Granules: Dissolve sunset yellow in 5% (w / w) hydroxypropyl methylcellulose (50cp) to obtain an aqueous binder solution containing pigment. After mixin...

Embodiment 2

[0022] Acid Granules Recipe:

[0023] Vitamin C (40 mesh-60 mesh) 450g; citric acid (40 mesh-60 mesh) 910g; sunset yellow 2g.

[0024] Alkali grain formula:

[0025] Sodium carbonate 1060g; Sodium chloride 6g; Sucrose 600g; Aspartame 25g; Sunset yellow 8g; Polyvinylpyrrolidone 8g.

[0026] Preparation process: Acid granules: Dissolve the prescribed amount of sunset yellow in an appropriate amount of 80% ethanol aqueous solution by ultrasonic to obtain an ethanol aqueous solution containing pigment. After mixing vitamin C and citric acid evenly according to the prescription amount, the soft material is prepared with the prepared ethanol aqueous solution containing pigment, granulated with a 24-mesh sieve, dried at 50°C, and sieved through a 16-mesh sieve and a 60-mesh sieve respectively.

[0027] Alkali particles: Dissolve sunset yellow in 12% (w / w) polyvinylpyrrolidone aqueous solution to obtain an aqueous binder solution containing pigment. Mix sodium carbonate, sodium chl...

Embodiment 3

[0030] Acid Granules Recipe:

[0031] Vitamin C (40-60 mesh) 200g; malic acid (40-60mesh) 1200g; tartrazine 1.5g.

[0032] Alkali grain formula:

[0033] Sodium bicarbonate 1320g; Sodium chloride 10g; Sucrose 100g; Aspartame 60g; Tartrazine 8.5g; Syrup 6g.

[0034] Preparation process: acid granule: Dissolve the prescribed amount of tartrazine in an appropriate amount of 70% ethanol aqueous solution by ultrasonic to obtain an ethanol aqueous solution containing pigment. After mixing vitamin C and malic acid evenly according to the prescription amount, the soft material is prepared with the prepared ethanol aqueous solution containing pigment, granulated with a 20-mesh sieve, dried at 40°C, and sieved through a 16-mesh sieve and a 60-mesh sieve respectively.

[0035] Alkali granules: Dissolve lemon yellow in 10% aqueous syrup solution to obtain an aqueous binder solution containing pigment. After mixing sodium bicarbonate, sodium chloride, sucrose and aspartame evenly accord...

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Abstract

The invention discloses a vitamin C effervescent granule and a preparation method thereof applied to the field of preparations of vitamin C. The vitamin C effervescent granule comprises acid granules and alkali granules; the acid granules mainly comprise vitamin C and effervescent agent acid sources; the alkali granules mainly comprise effervescent agent alkali sources; the effervescent agent acid sources are effervescent agent acid sources crystals; or the effervescent agent acid sources are the effervescent agent acid source crystals and the vitamin C which is a vitamin C crystal. The preparation method comprises the steps of respectively preparing the acid granules and the alkali granules; and packaging the acid granules and the alkali granules according to the proportion of a prescription to obtain the VC effervescent granule. According to the vitamin C effervescent granule and the preparation method thereof disclosed by the invention, the acid granules are prepared from the effervescent agent acid source crystals and the vitamin C crystal, so that the disintegration speed of the vitamin C effervescent granule is improved and the effervescent granule can be quickly disintegrated at a lower water temperature; and meanwhile, the stability of the vitamin C effervescent granule is improved by adopting accessories with small hygroscopicity, and thus the storage and the transportation of the vitamin C are facilitated.

Description

technical field [0001] The invention relates to vitamin C effervescent granules in the field of vitamin C preparations and a preparation method thereof. Background technique [0002] Vitamin C is an essential substance to maintain the normal life process of the body. It participates in various reactions in the body, and has various functions such as promoting the synthesis of collagen, treating scurvy, and preventing arteriosclerosis. At present, the dosage forms of vitamin C mainly include injections, pills, ordinary tablets, effervescent tablets, ordinary granules and effervescent granules, etc. Among them, vitamin C effervescent granules are a novel dosage form developed and applied abroad in recent years. , due to the characteristics of fast disintegration, convenient taking, fast absorption, high bioavailability, rapid onset of action, convenient carrying, storage and transportation, etc., it is more and more popular with patients, especially suitable for children, the ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/375A61K47/38A61K47/32A61K47/26A61P3/02
Inventor 王慧颖陈雅琴李想王玲玲鲍辉李芳石秀芹郭凤尧周联波
Owner SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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