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Preparation method of antimicrobial peptide slow-release microcapsules

A technology for sustained-release microcapsules and antimicrobial peptides, applied in the field of preparation of microcapsules, can solve the problems of difficulty in forming industrialized large-scale production, lack of sustained-release coating for antimicrobial peptides, and the like, and achieve the effect of uniform embedding

Active Publication Date: 2012-12-19
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problems that the existing chitosan / sodium alginate microcapsule preparation method is only suitable for laboratory or small-scale production, it is difficult to form industrialized large-scale production and the existing antibacterial peptides also lack effective slow-release coatings

Method used

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Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0014] Embodiment 1: In this embodiment, antibacterial peptide sustained-release microcapsules are prepared according to the following steps:

[0015] 1. Mix the sodium alginate aqueous solution and chitosan acid solution with a high-speed homogenizer to form sustained-release granules;

[0016] 2. Put the antimicrobial peptide and slow-release granules together into a medical mixer for embedding to obtain antimicrobial peptide microparticles, and then embed the antimicrobial peptide microparticles with β-cyclodextrin to obtain antimicrobial peptide sustained-release microcapsules.

specific Embodiment approach 2

[0017] Specific embodiment two: the difference between this embodiment and specific embodiment one is: chitosan mass concentration is 0.25% (W / V)~1.5% (W / V) in the chitosan acid solution in the step 1, removes The degree of acetylation is 82% to 85%, and the molecular weight of chitosan is 3.3×10 5 ~4.6×10 5 of high molecular weight chitosan and a molecular weight of 0.72×10 5 ~1.19×10 5 The low molecular weight chitosan is composed according to the mass ratio of 1:1; and glucose is added into the chitosan acid solution, and the molar ratio of chitosan to glucose in the chitosan acid solution is 0.3-0.8. Other steps and parameters are the same as those in Embodiment 1.

[0018] In this embodiment, the concentration of the chitosan acid solution needs to be ≥0.25% (W / V), and the concentration of the chitosan acid solution increases, and the controllability of the microcapsules increases.

[0019] In this embodiment, glucose is added as a plasticizer, which can increase the ...

specific Embodiment approach 3

[0021] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the mass concentration of sodium alginate in the sodium alginate aqueous solution in step 1 is 1.5% to 2.0%. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of antimicrobial peptide slow-release microcapsules and relates to a preparation method of microcapsules. The invention solves the problems that a preparation mode of the existing chitosan / sodium alginate microcapsules is only suitable for laboratories or the small-scale production, the industrial large-scale production is difficult to form and the existing antimicrobial peptide is short of an effectively slow-release envelope. The preparation method comprises the following steps of: 1, uniformly mixing aqueous solution of sodium alginate and chitosan acid solution by a high-speed homogeneous machine to form slow-release particles; and 2, adding the antimicrobial peptide and the slow-release particles into a medical mixer together to carry out embedding to obtain antimicrobial peptide particles and then carrying out beta-cyclodextrin embedding on the antimicrobial peptide particles to obtain the antimicrobial peptide slow-release microcapsules. The preparation method can be used for producing an antimicrobial peptide medicament and has a very large development space in the field of medicine.

Description

technical field [0001] The invention relates to a preparation method of microcapsules. Background technique [0002] Microcapsule technology, also known as microcapsule embedding technology, or microcapsule granulation technology, is a technology that embeds solid, liquid and gaseous substances in the same microcapsule to become a solid particle. Usually, the material constituting the shell of the microcapsule is called "wall material" or "coating", and the material wrapped inside the microcapsule is called "capsule core" or "core material". The core material can be solid, liquid or gaseous. [0003] Generally, microencapsulation methods are roughly divided into three categories, chemical methods, physical methods, and physicochemical methods. Among them, chemical methods include interface polymerization method, in-situ polymerization method, orifice-solidification method, envelope method, etc.; physical methods include pot method, air suspension method, spray method, extr...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/50A61K38/10A61K47/36A61P31/04
Inventor 曲琪环
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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