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Medicine for treating gout and preparation method thereof

A medicine and a technology for gout are applied in the field of medicines for treating gout and their preparation, and can solve problems such as strong nephrotoxicity and the like

Inactive Publication Date: 2012-12-19
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through animal experiments and clinical observations, the treatment of gout has a good curative effect, and no toxicity was found in the acute toxicity test of mice, but the long-term toxicity test of mice for 6 months found that the invention has strong nephrotoxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Embodiment 1: the granule preparation of medicine of the present invention

[0132] Weigh 1500g of Atractylodes atractylodes, 2000g of Smilax tuckahoe, 1000g of Phellodendron phellodendri, 1000g of Mianzi 1000g, 1000g of astragalus, 1000g of Alisma 1000g, and 1000g of Achyranthes bidentata.

[0133] The above-mentioned crude drug is prepared according to the following method:

[0134] a) Adding 70% ethanol to the Cortex Phellodendri in the weight ratio and refluxing extraction twice, the first time is 2 hours, and the second time is 1 hour. Combine the medicinal liquids, filter the medicinal liquids, recover ethanol, and obtain an alcohol extract;

[0135] b) Decoct the herb dregs after alcohol extraction of Atractylodes atractylodis, Smilax tuckahoe, Mianzi, Astragalus, Alisma, Achyranthes bidentata and Cortex Phellodendri in the stated weight ratio, add water to decoct twice, add 12 times the amount of water for the first time, and decoct For 2 hours, add 10 times t...

Embodiment 2

[0138] Embodiment 2: the granule preparation of medicine of the present invention

[0139] Take by weighing Atractylodes atractylodis 2000g, Smilax 2500g, Cortex Phellodendron 1500g, Mianzi 1500g, Astragalus 1500g, Alisma 1500g, Achyranthes bidentata 1500g;

[0140] The above-mentioned crude drug is prepared according to the following method:

[0141] a) Add 10 times of 96% ethanol to the Cortex Cortex Phellodendron by weight and extract twice by refluxing, the first time is 2 hours, and the second time is 1 hour. Combine the medicinal liquids, filter the medicinal liquids, recover ethanol, and obtain an alcohol extract;

[0142] b) Decoct the herb dregs after alcohol extraction of Atractylodes atractylodis, Smilax tuckahoe, Mianzi, Astragalus, Alisma, Achyranthes bidentata and Cortex Phellodendri in the stated weight ratio, add water to decoct twice, add 12 times the amount of water for the first time, and decoct For 2 hours, add 10 times the amount of water for the second ...

Embodiment 3

[0145] Embodiment 3: the granule preparation of medicine of the present invention

[0146] Weigh 500g of Atractylodes atractylodes, 1000g of Smilax tuckahoe, 500g of Phellodendron phellodendri, 300g of Mianzi 300g, 300g of astragalus, 300g of Alisma, 300g of Achyranthes bidentata;

[0147] The above-mentioned crude drug is prepared according to the following method:

[0148] a) Add 60% ethanol to the Cortex Cortex Phellodendron with 8 times of reflux to extract twice, the first time is 2 hours, and the second time is 1 hour. Combine the medicinal liquids, filter the medicinal liquids, recover ethanol, and obtain an alcohol extract;

[0149]b) Decoct the herb dregs after the alcohol extraction of Atractylodes atractylodis, Smilax tuckahoe, Mianzi, Astragalus, Alisma, Achyranthes bidentata and Cortex Phellodendri in the stated weight ratio, add water to decoct twice, add 15 times the amount of water for the first time, and decoct For 2 hours, add 8 times the amount of water fo...

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Abstract

The invention relates to a medicine for treating gout and a preparation method thereof, belonging to the technical field of medicines. The medicine is prepared from rhizoma atractylodis, cortex phellodendri, achyranthes bidentata, rhizoma smilacis glabrae, rhizoma dioscoreae septemlobae, radix astragali and rhizoma alismatis, is prepared by water extraction and alcohol precipitation according to certain proportions, and can be prepared into any common dosage form for oral administration. The medicine provided by the invention has good effect and high efficiency and is non-toxic and convenient to use when treating gout.

Description

technical field [0001] The invention relates to a medicine for treating gout and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Gout is one of the oldest metabolic diseases of human beings, and it is also a worldwide disease all over the world. As early as many years BC, there were cases of gout in medical literature, but the real understanding of gout has gone through a long process of nearly a thousand years, and a comprehensive understanding of the etiology and pathogenesis of gout has only been achieved in recent decades. Certain progress. Clinical research results show that congenital factors such as heredity and acquired factors such as diet and lifestyle are the key factors leading to elevated blood uric acid and gout. [0003] In my country, with the continuous changes in people's work, lifestyle and diet, the number of patients with hyperuricemia and gout is increasing year by year. It is estimated that g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61P19/06
Inventor 李诗标张为胜苏静张梅雪张晶
Owner JINAN KANGZHONG PHARMA TECH DEV
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