Medicinal application of angiostatin

Abstract

The invention discloses a medicinal application of angiostatin; the angiostatin can be used as an active component for preparing anti-inflammatory medicaments; when determined by a reductive SDS-PAGE method, the angiostatin used as an active component of an anti-inflammatory medicament exhibits two bands which are an alpha chain and a beta chain respectively; the molecular weights are 12000-22000 Dalton and 9000-19000 Dalton respectively; the amino acid sequence of the alpha chain is shown in SEQ ID NO.1, and the amino acid sequence of the beta chain is shown in SEQ ID NO.2; after dimensional electrophoresis, three isomers corresponding to the alpha chain and three isomers corresponding to the beta chain are respectively generated. The angiostatin found in the research of the invention can be used as a novel natural protein anti-inflammatory medicament, which has no obvious toxic or side effect on human body, has wide application prospects, and provides another development of traditional anti-inflammatory medicament research.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a pharmaceutical application of a biological material. More specifically, the invention studies the application of an angiostatin as an active ingredient of an anti-inflammatory drug. Background technique [0002] Angiostatin, also known as angiostatin and angiostatin, is a natural hydrolysis product of plasminogen in the body, which can effectively inhibit the proliferation, migration and formation of tubular structures of vascular endothelial cells. Involved in the regulation of angiogenesis. Angiogenesis refers to the process of growing new branched blood vessels from existing blood vessels. This process plays an important role in the formation of embryonic developmental tissues and organs, but is not active in general adult tissues (except for tissues such as the female reproductive system). However, under certain pathological conditions, such as wound healin...

AI Technical Summary

Problems solved by technology

Although steroidal drugs have excellent curative effect, long-term use can cause serious disturbance of water-salt metabolism and sugar, fat, and protein metabolism; non-steroidal drugs are currently the most widely used drugs for clinical inflammation treatment, because NSAIDs inhibit It inhibits the synthesis of prostaglandins (PGs), so while it plays an anti-inflammatory role, it also causes side effects on the gastrointestinal tract, mainly manifested as upper gastrointestinal bleeding caused by gastric and duodenal ulcers; it can also cause sodium water Retention and edema, hyperemia, nephrotic syndrome complicated with interstitial nephritis, renal insufficiency, acute interstitial nephri

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