Preparation process of salicin comparison product

A preparation process, a technology for crude salicin, applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives and other directions

Inactive Publication Date: 2013-01-09
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are certain defects in the preparation process of the salicin reference substance in the prior art, which needs to be improved to better meet the requirements of the traditional Chinese medicine standard substance

Method used

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  • Preparation process of salicin comparison product
  • Preparation process of salicin comparison product
  • Preparation process of salicin comparison product

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Embodiment Construction

[0020] In order for those skilled in the art to better understand the technical solutions provided by the present invention, the following will be described in conjunction with specific embodiments.

[0021] The preparation process of the salicin reference substance provided by the embodiments of the present invention comprises the following steps:

[0022] (1) Extraction of salicin from poplar flowers: Take 4kg of poplar flowers, cut them into pieces, add 15 times the amount of water to decoct and extract twice, each time for 1.5h, combine the two liquids, filter, let the filtrate stand overnight, and take the upper layer to clarify the extract A , (about 95L), spare;

[0023] (2) Preliminary separation of salicin by macroporous resin, including the following steps (21) and (22):

[0024] (21) Pretreatment of macroporous resin: take macroporous resin D-1015kg, add acetone 8000-10000ml, stir, soak for 12 hours, put into chromatography column, drain acetone, rinse with distill...

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Abstract

The invention discloses a preparation process of a salicin comparison product. The preparation process includes following steps of extracting salicin from poplar flowers; preliminarily separating the salicin by using macroporous resins; extracting n-butanol; separating and purifying the salicin by means of a normal phase silica gel method; and recrystallizing the salicin. Compared with preparation processes in prior art, the preparation process of the salicin comparison product can well meet requirements of traditional Chinese medicine standard products.

Description

technical field [0001] The invention relates to the field of preparation of a reference substance, in particular to a preparation process of a salicin reference substance. Background technique [0002] Salicin is white crystal; taste bitter; melting point 199~202℃, specific optical rotation [α] 厍-45.6° (0.6g / 100cm3 absolute ethanol); soluble in water, easily soluble in boiling water, insoluble Soluble in ethanol (1:90), insoluble in ether or chloroform, but soluble in alkali solution, pyridine or glacial acetic acid, its aqueous solution has a neutral reaction, there is no free phenolic hydroxyl group in the molecule, and it belongs to phenolic glycoside compounds; Or hydrolyzed by amygdalin to produce glucose and salicyl alcohol. The molecular formula of salicyl alcohol is C7H8O2; it is orthorhombic colorless needle crystal; the melting point is 86-87°C; it sublimes when heated to 100°C; it is soluble in water and benzene, easily soluble in ethanol, ether, and chloroform; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08
Inventor 房春林吴学渊李超杨海涵李犹平
Owner CHENGDU QIANKUN VETERINARY PHARMA
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