Quinolone metal complex containing polyacid anion and preparation method thereof

A technology of metal complexes and anions, applied in organic chemistry, antibacterial drugs, etc., can solve problems such as poor antibacterial and antibacterial effects, and achieve the effects of good antibacterial effect, reduced drug dosage, and good medicinal prospects.

Inactive Publication Date: 2013-01-16
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the existing quinolone metal complexes have poor antibacterial and antibacterial effects, and the proposed quinolone metal complexes containing polyacid anions and their preparation method

Method used

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  • Quinolone metal complex containing polyacid anion and preparation method thereof
  • Quinolone metal complex containing polyacid anion and preparation method thereof
  • Quinolone metal complex containing polyacid anion and preparation method thereof

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specific Embodiment approach 1

[0029] Specific embodiment one: the structural formula of the quinolone metal complex containing polyacid anion of the present embodiment is

[0030]

[0031] Among them, R 1 is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl or substituted aryl, R 2 is ethyl or cyclopropyl, R 3 is hydrogen or amino, R 4 is hydrogen, fluorine, chlorine or amino, R 5 is methyl, piperazinyl, halogen or hydrogen, R 6 is hydrogen or methoxy, X and Y are both carbon or nitrogen atoms, M 1 For the transition metal cation ion Fe 3+ 、Co 2+ 、Ni 2+ 、Cu 2+ 、Cr 3+ , Zn 2+ or CD 2+ ,M 2 For Si or P.

specific Embodiment approach 2

[0032] Specific embodiment two: the preparation method of the quinolone metal complex containing polyacid anion in this embodiment is realized according to the following steps:

[0033] 1. Add the compound containing polyacid anions and the compound containing transition metal cation ions into the Erlenmeyer flask according to the molar ratio of polyacid anion and transition metal cation ion is 1: (1~4), after stirring evenly, press distilled water and The molar ratio of polyacid anions is (4~6): 1. Add distilled water into the Erlenmeyer flask, mix and stir for 0.5~1h, and prepare a compound solution containing polyacid anions and transition metal cations;

[0034] 2. Put quinolone and the compound containing transition metal cation ions into the beaker according to the molar ratio of quinolone to transition metal cation ion is 2: (1~5), and then according to the molar ratio of distilled water to quinolone (3~5): 1 Add distilled water in the beaker, stir and dissolve to obtai...

specific Embodiment approach 3

[0045] Embodiment 3: This embodiment is different from Embodiment 2 in that in step 1, the molar ratio of polyacid anions to transition metal cations is 1: (1.5~3.5) and added to the conical flask. Other steps and parameters are the same as in the second embodiment.

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Abstract

The invention relates to a quinolone metal complex containing polyacid anions and a preparation method thereof, belonging to the field of researches on quinolone metal complexes and preparation methods thereof. The invention provides the quinolone metal complex containing polyacid anions and the preparation method thereof, aiming at solving the problems of poor antibacterial and bacteriostatic effects of the existing quinolone metal complex. The quinolone metal complex containing polyacid anions consists of ternary complexes and free quinolone cations, wherein the ternary complexes consist of polyacid anions, transition metal anions and quinolone molecules. The preparation method comprises the following steps of: 1) preparing compound solution containing polyacid anions, transition metal anions; 2) preparing quinolone metal complex solution; 3) obtaining crystals or powder; and 4) preparing the quinolone metal complex included by polyacid anions. The quinolone metal complex containing polyacid anions and the preparation method thereof are used in the fields of quinolone metal complexes containing polyacid anions and preparation methods thereof.

Description

technical field [0001] The invention relates to a quinolone metal complex and a preparation method thereof. Background technique [0002] At present, the widespread use of quinolones as clinical antibacterial drugs has led to the emergence of drug resistance, so satisfactory antibacterial and bacteriostatic effects cannot be obtained, and quinolone metal complex drugs have been extensively studied. The 3-position carboxyl group and the 4-position keto group of the quinolone drug molecule can simultaneously chelate and coordinate with the transition metal cation ion to form a quinolone metal complex drug. Most of the reported antibacterial activities of these metal complexes are equivalent to their ligands, and a small number of complexes have stronger or weaker antibacterial activities than the corresponding ligands. Aiming at the emergence of drug resistance, the problem of poor antibacterial and antibacterial effects, the present invention has done a large amount of test ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04A61P31/04
Inventor 刘红杨洪伟刘岩张瑞仁刘凤华宋春香刘海燕刘立新张羽男缪月英
Owner JIAMUSI UNIVERSITY
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