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Application of Houttuynoid B in medicament for resisting tubercle bacillus

A technology for anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effects of strong tuberculosis inhibitory activity, prominent substantive features, and broad application prospects

Inactive Publication Date: 2013-01-23
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of Houttuynoid B in medicament for resisting tubercle bacillus
  • Application of Houttuynoid B in medicament for resisting tubercle bacillus
  • Application of Houttuynoid B in medicament for resisting tubercle bacillus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of compound Houttuynoid B tablet involved in the present invention:

[0017] Take 20 grams of compound Houttuynoid B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0018] Embodiment 2: the preparation of compound Houttuynoid B capsules involved in the present invention:

[0019] Take 20 grams of compound Houttuynoid B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1 Determination of absolute concentration of Houttuynoid B against BCG by solid medium dilution method

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1 ) turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] Make Houttuynoid B into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Houttuynoid B to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50~55°C), mixed evenly to make Houttuynoid B, the concentrations are 6.0 ug / ml, 4.0 ug / ml, 3.0 ug / ml, 2.0 ug / ml...

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PUM

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Abstract

The invention discloses an application of Houttuynoid B in the preparation of a medicament for resisting tubercle bacillus. Aiming at the current situation that the disease incidence and the mortality rate of tuberculosis have ascending trends due to high disease incidence of tuberculosis and the appearance of tubercle bacillus multiple drug-resistant strains at present, Houttuynoid B has the characteristic of obviously inhibiting the activity of tubercle bacillus and has good application prospect. The application of Houttuynoid B in the preparation of a medicament for resisting tubercle bacillus is firstly disclosed; since the skeleton type belongs to an entirely new skeleton type and the activity for inhibiting tubercle bacillus is previously unimagined high without any possibility of giving out revelation by other compounds, the application has outstanding substantial characteristics; and simultaneously, the application for preventing and treating tubercle bacillus infection is obviously advanced.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Houttuynoid B in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregular treatment ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/06
Inventor 邱翔宇王慧吴俊华
Owner 吴俊华
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