Unlock instant, AI-driven research and patent intelligence for your innovation.

Magnolol supercritical extraction method

A magnolol and supercritical technology, applied in chemical instruments and methods, production of bulk chemicals, preparation of organic compounds, etc., can solve problems such as low purity of extracted products, poisoning of the environment by operators, waste of Chinese medicinal materials, etc., to achieve The effect of saving Chinese herbal medicines, preventing oxidation and dissipation, and reducing costs

Inactive Publication Date: 2013-01-30
BEICHUAN ANTE NATURAL PHARMA
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general extraction method adopts the traditional decoction method plus chemical extraction. The extraction process uses organic solvents, and there are organic solvent residues, which cause poison to the operator and pollute the environment, consume energy, and the purity of the extracted product is not high.
Magnolia officinalis will die after the bark is peeled off, so using the bark to extract active ingredients to make Chinese patent medicines or extracting magnolol is a waste of Chinese medicinal materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 of the present invention: Magnolia officinalis leaves are superfinely pulverized to 40 mesh or more, soaked in CO2 liquid for 2-4 hours, the entrainer ethanol weight in the CO2 soaking liquid is 10% of the CO2 liquid weight, and the extraction kettle is controlled The medium pressure is 23-28MPa. After soaking, separate in the separation kettle. Control the separation pressure in the separation kettle to 5-8MPa. The CO2 flow rate is maintained at 25Kg–35 Kg / h. The pressure in the separation kettle is 6MPa, gradually heated to 38°C to precipitate magnolol, take it out, continue to heat to 38-42°C to precipitate honokiol; dry magnolol and honokiol. In this embodiment, the extraction rate is more than 90%, and the total content of magnolol and honokiol in the extract is about 60%, with good quality and no solvent residue.

Embodiment 2

[0015] Embodiment two: Magnolia officinalis leaves are ultrafinely pulverized to 40 orders and more than 40 orders, soaked in CO2 in the liquid for 2-4 hours, the entrainer methanol weight in the CO2 soaking liquid is 4% of the weight of the CO2 liquid, and the pressure in the extraction kettle is controlled 23-28MPa, separate in the separation kettle after soaking, control the separation pressure in the separation kettle to 5-8MPa, maintain the flow rate of CO2 at 25Kg–35 Kg / h, put it into the fractionation separation kettle for separation, control the separation kettle Medium pressure 6MPa, gradually heated to 38°C to precipitate magnolol, take it out, continue heating to 38-42°C to precipitate honokiol; dry magnolol and honokiol.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an extraction method of a traditional Chinese medicinal material magnolol, and especially relates to a method for preparing the magnolol through the CO2 supercritical extraction of Leaf of Magnolia officinalis. The method comprises the following steps: carrying out ultrafine crushing of the Leaf of Magnolia officinali to 40 meshes or above 40 meshes, immersing the powder of the Leaf of Magnolia officinali obtained after crushing in a CO2 liquid in an extraction kettle under a pressure of 23-28MPa for 2-4h, separating in a separation kettle under a pressure of 5-8MPa, at a temperature of 35-42DEG C and under a CO2 flow of 25-35Kg / h for 4-6h, and drying the separated extract to obtain the magnolol. The method enables the extraction rate to reach above 90%, the total content of the magnolol in the extract to reach about 60%, the magnolol quality to be good and no solvents to be residual, and simultaneously has the advantages of maintenance of all components of the medicinal plant in the extract, high extraction efficiency, less energy consumption, cost saving, and prevention of the poisoning of the extraction process to human bodies and the pollution of the extraction process to the environment.

Description

technical field [0001] The present invention relates to the extracting method of magnolol of Chinese medicinal material, particularly use Magnolia officinalis leaf through CO 2 A method for extracting magnolol by supercritical extraction. Background technique [0002] Magnolia officinalis is a traditional Chinese medicinal material in my country, and its bark and leaves contain magnolol with high medicinal value. Due to the low polarity of this type of compound, although most of it can be extracted by ethanol reflux extraction or percolation extraction, the yield can reach more than 80%, but in the process of concentration, with the reduction of alcohol content, it will be recovered again. Precipitate from the solution, adhere to the surface of the wall or form a rubber-like substance that precipitates at the bottom, reducing the yield. Ethanol reflux extraction, concentration, drying, the average yield of magnolol and honokiol in the dry extract is only 20% to 30%. Howev...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/82
CPCY02P20/54
Inventor 王健鹏
Owner BEICHUAN ANTE NATURAL PHARMA