Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of resveratrol microcapsule

A technology of resveratrol and microcapsules, which is applied in the field of preparation of resveratrol microcapsules, can solve problems such as poor water solubility of resveratrol, and achieve the effects of easy industrial production, high stability and simple operation.

Active Publication Date: 2013-02-06
晨光生物科技集团天津有限公司
View PDF5 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Resveratrol is poorly soluble in water

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method for the preparation of resveratrol microcapsules, comprising the steps of:

[0022] (1) dissolving resveratrol in ethanol aqueous solution with a volume concentration of 75% as a solvent, adding emulsifier starch sugar fatty acid ester, passing through a colloid mill for 30min at 25°C, and mixing to make a core material solution, the obtained The mass ratio of resveratrol, solvent and emulsifier is 1:2:5;

[0023] (2) Add water to the chitosan, stir at 40°C for 1.5 hours to make the chitosan swell and disperse to make a wall material solution, the mass ratio of the chitosan to water is 1:10;

[0024] (3) According to the mass ratio of 1:20, add the core material solution to the wall material solution at 40°C to obtain a mixed solution, homogeneously emulsify into a white emulsion with a colloid mill, add a curing agent, and continue to use the colloid mill After homogenizing for 45 minutes, resveratrol microcapsules with good dispersibility were obtained after...

Embodiment 2

[0027] A method for the preparation of resveratrol microcapsules, comprising the steps of:

[0028] (1) resveratrol is dissolved in the ethanol aqueous solution that volume concentration is 20% as solvent, adds emulsifier sodium lauroyl lactylate, passes colloid mill 40min at 20 ℃, mixes and makes core material solution, described resveratrol The mass ratio of revertyl alcohol, solvent and emulsifier is 1:0.5:0.1;

[0029] (2) Add water to the chitosan, stir at 40°C for 2 hours to make the chitosan swell and disperse to make a wall material solution, the mass ratio of the chitosan to water is 1:1;

[0030] (3) According to the mass ratio of 1:10, add the core material solution to the wall material solution while stirring at 30°C to obtain a mixed solution, which is homogeneously emulsified into a white emulsion by the colloid mill, and the curing agent is added to continue Homogenize with a colloid mill for 40min, and spray-dry to obtain resveratrol microcapsules with good di...

Embodiment 3

[0033] A method for the preparation of resveratrol microcapsules, comprising the steps of:

[0034] (1) resveratrol is dissolved in the ethanol aqueous solution that is 50% in the volume concentration as solvent, adds the alkenyl succinic acid starch sugar ester and starch sugar fatty acid ester that mass ratio is 1:1 as emulsifier, at 30 Pass through a colloid mill for 20 minutes at °C, and mix to make a core material solution. The mass ratio of resveratrol, solvent and emulsifier is 1:5:5;

[0035] (2) Add water to the chitosan, stir at 30°C for 3 hours to make the chitosan swell and disperse to make a wall material solution, the mass ratio of the chitosan to water is 1:20;

[0036] (3) According to the mass ratio of 1:30, add the core material solution to the wall material solution while stirring at 50°C to obtain a mixed solution, which is homogeneously emulsified into a white emulsion by the colloid mill, and the curing agent is added to continue Use a colloid mill to ho...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a resveratrol microcapsule, and the method comprises the following steps of: (1) dissolving resveratrol into a solvent, adding an emulsifying agent, and evenly mixing to obtain the core material solution by means of colloid mill; (2) adding water into chitosan, stirring, and swelling and dispersing the chitosan to prepare a wall material solution; and (3) stirring the core material solution and adding the core material solution into the wall material solution to obtain a mixed solution, homogenizing and emulsifying into white lactescence by means of colloid mill, adding a curing agent, continuously homogenizing by means of a colloid mill, and carrying out spray drying to obtain the resveratrol microcapsule with good dispersity. The resveratrol microcapsule prepared by the method provided by the invention is good in solubility and high in stability. The method provided by the invention is simple to operate, and easy for industrial production.

Description

technical field [0001] The invention relates to a preparation method of resveratrol microcapsules. Background technique [0002] Resveratrol is a polyphenolic compound widely present in higher plants. It is a natural antioxidant that can reduce blood viscosity, inhibit platelet aggregation and vasodilation, keep blood flowing, delay aging, regulate Blood lipids, protection of cardiovascular and cerebrovascular, anti-hepatitis and other functions, can prevent and treat chronic inflammation caused by pathogenic microbial infection. Resveratrol contains many complement active factors, which are beneficial to the human body. Research scholars have pointed out that the use of resveratrol can effectively treat cardiovascular diseases and cancer. [0003] Microencapsulation technology is a new technology developed rapidly in the past 20 years. It uses natural or synthetic polymer materials to wrap solid, liquid, and gas tiny particles in a microcapsule with a diameter of 1 to 50...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/50A61K31/05A61K47/36A61P9/00A61P35/00
Inventor 张卫军王如
Owner 晨光生物科技集团天津有限公司