Florfenicol suspension injection and preparation procedure thereof

A technology of suspension injection and florfenicol, which is applied in the direction of liquid delivery, emulsion delivery, antibacterial drugs, etc., can solve the problems of high production cost, achieve low production cost, good needle penetration, and simple preparation method Effect

Inactive Publication Date: 2013-02-13
HARBIN WILLHOPE ANIMAL HEALTH CARE PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the florfenicol injections used in China are all oil-phase injections, and the production cost is high. Generally, it is used twice a day for 3 to 5 consecutive days.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0022] Specific embodiment one: the preparation technology of the florfenicol suspension injection of the present embodiment is as follows:

[0023] (1) Dissolve 2 parts by weight of hypromellose and 1 part by weight of sodium carboxymethylcellulose with 200 parts by volume of water for injection to make a glue to obtain solution 1;

[0024] (2) Mix 40 parts by weight of fat-soluble florfenicol with 1.3 parts by weight of Tween-80 and 0.7 parts by weight of Span-80, and add water to make a suspension to obtain solution 2;

[0025] (3) Slowly add solution 1 to solution 2 under stirring;

[0026] (4) Add 1 part by weight of citric acid, 0.4 parts by weight of sodium citrate, 1.5 parts by weight of butylated hydroxytoluene, 10 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;

[0027] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;

[0028] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by ...

specific Embodiment approach 2

[0040] Specific embodiment two: the preparation process method of the florfenicol suspension injection of the present embodiment is as follows:

[0041] (1) Dissolve 1.5 parts by weight of sodium carboxymethylcellulose with 200 parts by volume of water for injection to make a glue to obtain solution 1;

[0042] (2) Mix 50 parts by weight of fat-soluble florfenicol with 3 parts by weight of polyoxyethylene ether (40) hydrogenated castor oil, add water to make a suspension, and obtain solution 2;

[0043] (3) Slowly add solution 1 to solution 2 under stirring;

[0044] (4) Add 0.8 parts by weight of citric acid, 0.3 parts by weight of sodium citrate, 0.5 parts by weight of butylated hydroxytoluene, 5 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;

[0045] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;

[0046] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by fusing or sealing them in ...

specific Embodiment approach 3

[0047] Specific embodiment three: the preparation process method of the florfenicol suspension injection of the present embodiment is as follows:

[0048] (1) Dissolve 2 parts by weight of hypromellose and 1 part by weight of povidone with 200 parts by volume of water for injection to make a glue to obtain solution 1;

[0049] (2) Mix 50 parts by weight of fat-soluble florfenicol with 3 parts by weight of polyoxyethylene ether (40) hydrogenated castor oil, add water to make a suspension, and obtain solution 2;

[0050] (3) Slowly add solution 1 to solution 2 under stirring;

[0051] (4) Add 1 part by weight of citric acid, 0.5 part by weight of sodium citrate, 0.8 part by weight of butylated hydroxytoluene, 20 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;

[0052] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;

[0053] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by fusing or seal...

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Abstract

The invention discloses a florfenicol suspension injection and a preparation procedure thereof, and relates to a medicine and a preparation procedure. The drug substance of the florfenicol suspension injection provided by the invention comprises the following components in part by weight: 40-100 parts of fat soluble florfenicol, 1.5-5 parts of suspending agent, 2-4 parts of wetting agent, 0.8-1.2 parts of citric acid, 0.3-0.5 parts of sodium citrate, 0.5-1 part of butylated hydroxytoluene and 5-40 parts of benzyl alcohol. The preparation procedure comprises the following steps: water for injection is used to dissolve the prescribed suspending agent into rubber paste to get solution 1; fat soluble florfenicol is evenly mixed with a wetting agent and water is added into the mixture of the fat soluble florfenicol and the wetting agent to form suspension to get solution 2; solution 1 is slowly added to solution 2 while stirring; citric acid, sodium citrate, butylated hydroxytoluene and benzyl alcohol is added, and then water is added to get 1000 ml of suspension; and the suspension is split and packed after stirring for 30-40 minutes to get florfenicol suspension injection. The florfenicol suspension injection has the advantages of broad antibacterial effect, strong antibacterial activity, low dosing frequency, little stress response and low price.

Description

technical field [0001] The invention relates to a medicine and a preparation process thereof, in particular to a water-suspension long-acting injection of florfenicol, a chloramphenicol broad-spectrum antibacterial drug specially used for veterinary medicine, and a preparation process thereof. Background technique [0002] Florfenicol (florfenicol), also known as florfenicol, is a new type of veterinary-specific broad-spectrum antibacterial drug developed by Schering-Plough in 1988. Its chemical The name is D(+)-threo-1-p-thiamphenylphenyl-2-dichloroacetamido-3-fluoropropanol. Florfenicol is a structural homologue of chloramphenicol. Through structural modification and transformation, it has obvious advantages over chloramphenicol and thiamphenicol in terms of safety and efficacy. Moreover, florfenicol will not produce drug resistance similar to chloramphenicol and thiamphenicol mediated by plasmids, and it is still sensitive to many chloramphenicol-resistant strains. Many...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/165A61P31/04
Inventor 李文超胡海权秦国栋时国辉
Owner HARBIN WILLHOPE ANIMAL HEALTH CARE PROD CO LTD
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