Florfenicol suspension injection and preparation procedure thereof
A technology of suspension injection and florfenicol, which is applied in the direction of liquid delivery, emulsion delivery, antibacterial drugs, etc., can solve the problems of high production cost, achieve low production cost, good needle penetration, and simple preparation method Effect
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specific Embodiment approach 1
[0022] Specific embodiment one: the preparation technology of the florfenicol suspension injection of the present embodiment is as follows:
[0023] (1) Dissolve 2 parts by weight of hypromellose and 1 part by weight of sodium carboxymethylcellulose with 200 parts by volume of water for injection to make a glue to obtain solution 1;
[0024] (2) Mix 40 parts by weight of fat-soluble florfenicol with 1.3 parts by weight of Tween-80 and 0.7 parts by weight of Span-80, and add water to make a suspension to obtain solution 2;
[0025] (3) Slowly add solution 1 to solution 2 under stirring;
[0026] (4) Add 1 part by weight of citric acid, 0.4 parts by weight of sodium citrate, 1.5 parts by weight of butylated hydroxytoluene, 10 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;
[0027] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;
[0028] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by ...
specific Embodiment approach 2
[0040] Specific embodiment two: the preparation process method of the florfenicol suspension injection of the present embodiment is as follows:
[0041] (1) Dissolve 1.5 parts by weight of sodium carboxymethylcellulose with 200 parts by volume of water for injection to make a glue to obtain solution 1;
[0042] (2) Mix 50 parts by weight of fat-soluble florfenicol with 3 parts by weight of polyoxyethylene ether (40) hydrogenated castor oil, add water to make a suspension, and obtain solution 2;
[0043] (3) Slowly add solution 1 to solution 2 under stirring;
[0044] (4) Add 0.8 parts by weight of citric acid, 0.3 parts by weight of sodium citrate, 0.5 parts by weight of butylated hydroxytoluene, 5 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;
[0045] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;
[0046] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by fusing or sealing them in ...
specific Embodiment approach 3
[0047] Specific embodiment three: the preparation process method of the florfenicol suspension injection of the present embodiment is as follows:
[0048] (1) Dissolve 2 parts by weight of hypromellose and 1 part by weight of povidone with 200 parts by volume of water for injection to make a glue to obtain solution 1;
[0049] (2) Mix 50 parts by weight of fat-soluble florfenicol with 3 parts by weight of polyoxyethylene ether (40) hydrogenated castor oil, add water to make a suspension, and obtain solution 2;
[0050] (3) Slowly add solution 1 to solution 2 under stirring;
[0051] (4) Add 1 part by weight of citric acid, 0.5 part by weight of sodium citrate, 0.8 part by weight of butylated hydroxytoluene, 20 parts by weight of benzyl alcohol, and add water to 1000 parts by volume;
[0052] (5) Stir the solution at constant volume for 30 minutes to make it fully mixed;
[0053] (6) Finally, divide the solution into sterilized and dry ampoules and seal them by fusing or seal...
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