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Amoxicillin enrofloxacin oil suspension and preparation method thereof

A technology of oil suspension and amoxicillin, which is applied in the field of medicine and can solve problems such as difficulties in the preparation of oil suspension

Inactive Publication Date: 2017-05-31
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of oil suspensions, especially oil suspensions for injection, is relatively difficult. To obtain products with better physical stability, needle penetration and redispersibility, it is very critical to determine the type and amount of suitable excipients. Moreover, oil Suspensions have high requirements on the storage environment, and improving their storage stability is also a factor that needs to be considered during the preparation process

Method used

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  • Amoxicillin enrofloxacin oil suspension and preparation method thereof
  • Amoxicillin enrofloxacin oil suspension and preparation method thereof
  • Amoxicillin enrofloxacin oil suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 The preparation of amoxicillin enrofloxacin oil suspension of the present invention

[0025] Take a mixture of 60ml of soybean oil and 10ml of isopropyl myristate, heat (60°C-70°C) and mix well, then add vitamin C palm ester (0.01%-0.02%w / v), colloidal protective agent (aluminum silicate Magnesium: Magnesium stearate 1:1 mixture 5.0g) dissolved, add surfactant (soybean lecithin 0.3g, Tween-80 0.3g and Span-80 0.3g) to dissolve, then add suspending agent polyethylene glycol Alcohol 6000 5.0g is melted, stirred evenly, cooled to room temperature (15-25°C), added suspending agent polyvinylpyrrolidone K30 2.0g, stirred evenly, finally added amoxicillin 10g and enrofloxacin 10g, stirred evenly and used Soybean oil is settled to 100ml, homogeneous, obtains amoxicillin enrofloxacin oil suspension of the present invention.

Embodiment 2

[0026] Embodiment 2 Preparation of amoxicillin enrofloxacin oil suspension of the present invention

[0027] Take a mixture of 60ml of soybean oil and 10ml of isopropyl myristate, keep heating at 60°C-70°C, mix the oil phase evenly, add a colloidal protective agent (5.0g of a 1:1 mixture of magnesium aluminum silicate and magnesium stearate), Surfactant (soybean lecithin 0.3g, Tween-80 0.3g and Span-80 0.3g); the above mixture was cooled to room temperature (15-25°C), and suspending agent (polyethylene glycol 6000 5.0g and Polyvinylpyrrolidone K30 2.0g), stir evenly, finally add amoxicillin 10g and enrofloxacin 10g, after stirring evenly, use soybean oil to settle to 100ml, homogenize, obtain amoxicillin enrofloxacin oil of the present invention suspension.

[0028] The beneficial effects of the present invention are demonstrated through experimental examples below.

[0029] 1 material

[0030] Amoxicillin, North China Pharmaceutical Group; enrofloxacin, enrofloxacin hydroc...

experiment example 1

[0042] The influence of experimental example 1 oil phase type on the quality of amoxicillin enrofloxacin suspension

[0043] Soybean oil, rapeseed oil, peanut oil, corn oil, white oil, ethyl oleate, benzyl benzoate, and isopropyl myristate were used as the oil phase respectively, and the surfactant Span-80 (5%w / v), antioxidant p-hydroxytert-butylanisole (BHA) (0.02% w / v), thickener aluminum stearate (1% w / v) and main drug amoxicillin (10% w / v ), enrofloxacin (10% w / v) to prepare different suspensions, and investigate their sedimentation volume ratio, needle penetration, and dispersion after centrifugation. The results are shown in Table 1.

[0044] Table 1 adopts different kinds of oil phases to prepare the quality evaluation result of suspension

[0045]

[0046]It can be concluded from Table 1 that the amoxicillin and enrofloxacin suspension prepared with a single plant, mineral oil or ester as the oil phase cannot be dispersed after centrifugation, and the redispersibi...

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Abstract

The invention discloses an oil suspension. The oil suspension contains the following raw materials(per 100mL): 10g of amoxicillin, 10g of enrofloxacin or salts thereof, 0.9-1.0g of a surfactant, 5.0-5.1g of a colloid protectant, 4.0-7.0g of a suspending agent, 0.075-0.1g of an antioxidant, and the balance of an oil phase. Under the condition of adopting specific auxiliary materials and compounding ratio, the oil suspension prepared by the invention has good physical stability, syringeability and redispersion. The quality of the oil suspension is not lowered after the suspension is stored in a 60 DEG C environment for 10 days, so that the quality is stable.

Description

technical field [0001] The invention relates to amoxicillin and enrofloxacin oil suspension and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Amoxicillin, also known as amoxycillin or amoxycillin, is a white powder with a half-life of about 61.3 minutes, stable under acidic conditions, and a gastrointestinal absorption rate of 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. It is one of the most widely used oral semi-synthetic penicillins. Enrofloxacin, also known as ethyl ciprofloxacin, enrofloxacin, belongs to fluoroquinolone synthetic bacteriostatic agents. Enrofloxacin is a broad-spectrum bactericidal drug with special effects on mycoplasma, Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolytica, Staphylococcus aureus, streptococcus, etc. have bactericidal effect. [0003] Penicillin antibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/10A61K47/44A61K47/14A61K47/26A61K47/02A61K47/24A61K47/32A61K47/10A61K47/22A61P31/04A61K31/43
CPCA61K31/496A61K9/10A61K31/43A61K47/02A61K47/10A61K47/14A61K47/22A61K47/24A61K47/26A61K47/32A61K47/44A61K2300/00
Inventor 杨海涵李超唐华侨胡婷婷吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA
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