Oil suspension with procaine benzylpenicillin and method for preparing oil suspension

Abstract

The invention provides oil suspension with procaine benzylpenicillin. Every 100 mL of oil suspension contains raw and auxiliary materials including 5-45 g of procaine benzylpenicillin, 0.5-2 g of surfactants, 0.5-2 g of colloid protective agents, 2-5 g of suspending agents, 0-0.1 g of antioxidants and the balance oil phases. The oil suspension has the advantages that the oil suspension is high in sedimentation volume ratio and excellent in syringeability and re-dispersibility; deterioration of the quality of the oil suspension is unseen after the oil suspension is stored in environments at the temperatures of 4-60 DEG C for 3 months, and accordingly the oil suspension is stable in quality and has an excellent clinical application prospect.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a procaine penicillin oil suspension and a preparation method thereof. Background technique [0002] Procaine penicillin is the procaine salt of penicillin, and its antibacterial active ingredient is penicillin. Penicillin has good antibacterial activity against hemolytic Streptococcus and other Streptococcus, Streptococcus pneumoniae and non-penicillinase-producing Staphylococcus, Clostridium, Peptostreptococcus and melanin-producing Bacteroides and other anaerobic bacteria. Corynebacterium, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptococcus moniliforme, Listeria monocytogenes, Leptospira, and Treponema pallidum are also sensitive to penicillin. The antibacterial spectrum and mechanism of action of procaine penicillin are the same as that of penicillin, and both play a bactericidal effect by inhibiting the syn...

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Problems solved by technology

However, the preparation of oil suspensions, especially oil suspensions for injection, is relatively difficult. To obtain products with better physical stability, needle penetration and redispersibility, it is very critical to determine the type and amount of suitable excipients. Moreover, oil Suspensions have high requirements on the storage environment, and improving their storage stability is also a factor that needs to be considered during the preparation process

[0005] At present, there are also literature reports about procaine penicillin oil suspension. During the test, the applicant found that according to the standard of Veterinary Pharmacopoeia, the sedimentation volume ratio value is not high enough, and it does not disperse after being centrifuged at a speed of 4000r / min for 15min. , indicating that the existing procaine penicillin oil suspension has the problem of poor physical stability and poor quality, which needs further improvement

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