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Nicarbazin dry suspension and preparation method thereof

A technology for nicarbazine and dry suspension, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of simple preparation method, good uniformity and easy realization

Inactive Publication Date: 2016-05-04
黄利文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of nicarbazine's poor solubility in water and inconvenient administration greatly affect its use and curative effect in oral administration to animals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The prescription is as follows:

[0022] Each 100ml contains: 2.5g of nicarbazine, 1g of sodium carboxymethylcellulose, 0.1g of aspartame, 5ml of a mixture of dimethylacetamide and dimethyl phthalate (dimethylacetamide and o- Dimethyl phthalate = 8:2), soluble starch filling.

[0023] The preparation method is as follows:

[0024] (1) Preparation of clear solution: Accurately weigh nicarbazine according to the weight percentage, add the prescribed amount of solvent, and stir to completely dissolve nicarbazine to obtain a clear solution;

[0025] (2) Mixing: Add the prescribed amount of flavoring agent, carrier, and suspending agent to the solution successively, and mix evenly;

[0026] (3) Preparation of dry suspension: sieve the mixture prepared in step (2), dry in an incubator, and then sieve.

Embodiment 2

[0028] The prescription is as follows:

[0029] Each 100ml contains: 30g of nicarbazine, 10g of gum arabic powder, 2g of trisodium citrate, 30ml of a mixture of dimethylacetamide and dimethyl phthalate (dimethylacetamide and dimethyl phthalate ester=6:4), anhydrous sugar supplement.

[0030] The preparation method is as follows:

[0031] (1) Preparation of clear solution: Accurately weigh nicarbazine according to the weight percentage, add the prescribed amount of solvent, and stir to completely dissolve nicarbazine to obtain a clear solution;

[0032] (2) Mixing: Add the prescribed amount of flavoring agent, carrier, and suspending agent to the solution successively, and mix evenly;

[0033] (3) Preparation of dry suspension: sieve the mixture prepared in step (2), dry in an incubator, and then sieve.

Embodiment 3

[0035] The prescription is as follows:

[0036] Each 100ml contains: nicarbazine 10g, a mixture of 80% gum arabic powder and tragacanth gum, 1g sucralose, a mixture of dimethylacetamide and dimethyl phthalate (Dimethylacetamide and dimethyl phthalate = 6:4) 15ml of a mixture of dextrin and anhydrous sugar with a dextrin percentage of 30%.

[0037] The preparation method is as follows:

[0038] (1) Preparation of clear solution: Accurately weigh nicarbazine according to the weight percentage, add the prescribed amount of solvent, and stir to completely dissolve nicarbazine to obtain a clear solution;

[0039] (2) Mixing: Add the prescribed amount of flavoring agent, carrier, and suspending agent to the solution successively, and mix evenly;

[0040] (3) Preparation of dry suspension: sieve the mixture prepared in step (2), dry in an incubator, and then sieve.

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PUM

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Abstract

The invention discloses a nicarbazin dry suspension and a preparation method thereof, which belong to the field of veterinary preparations. The nicarbazin dry suspension consists of nicarbazin, a suspending aid, a solvent, corrigent and a carrier. The nicarbazin dry suspension has the characteristics of good drug homogeneity, simple preparation method, high sedimentation ratio, good solubility and the like and is likely to be accepted by affected animals.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a nicarbazine dry suspension and a preparation method thereof. Background technique [0002] Nicarbazine is effective against a variety of Eimeria in chickens, such as Eimeria tenacious, Eimeria fragilis, Eimeria poisonous, Eimeria giant, and Eimeria heap , Eimeria brucei have good control effect. However, the disadvantages of poor solubility in water and inconvenient administration of nicarbazine greatly affect the use and curative effect of nicarbazine in oral administration to animals. Contents of the invention [0003] To overcome the deficiencies in the prior art, the invention provides a nicarbazine dry suspension. [0004] To achieve the above object, the technical solution of the present invention is achieved in that: [0005] A nicarbazine dry suspension, consisting of 2.5-30% nicarbazine, 1-10% suspending agent, 0.1-2% flavoring agent, 5-30% ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/18A61K47/14A61K31/505A61P33/02
CPCA61K9/145A61K31/505
Inventor 黄利文
Owner 黄利文
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