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Preparation method of mixed suspension injection liquid for veterinary use

A technology for suspending injections and liquids, which can be used in medical preparations of non-active ingredients, liquid delivery, and pharmaceutical formulations. It can solve problems such as sensitivity, animal stress, and strong irritation of organic solvents, and achieve good photostability. , the effect of high sedimentation volume ratio

Active Publication Date: 2018-10-12
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The one-time investment of freeze-dried powder equipment is large, and the preparation is sensitive to light and heat. Some organic solvents are highly irritating and easily cause animal stress, while the use of vegetable oil is likely to cause drug deposition, which is difficult to shake and affect the use.

Method used

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  • Preparation method of mixed suspension injection liquid for veterinary use
  • Preparation method of mixed suspension injection liquid for veterinary use
  • Preparation method of mixed suspension injection liquid for veterinary use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, amoxicillin, colistin sulfate, ceftiofur, ceftiofur hydrochloride, ceftiofur sodium, tylosin tartrate, tyvanectin tartrate, tilmicosin, tilmicosin phosphate raw materials 5kg (raw materials are calculated as dry products, raw salt is calculated as dry products and raw materials); silicon dioxide 0.25kg; PEG-400 5kg; GTCC several.

[0018] Concrete preparation steps:

[0019] 1. Superfine pulverize the above raw materials so that the particle size is lower than 15um and take 5kg each for later use;

[0020] 2. Superfinely pulverize the silica to make the particle size less than 15um and take 0.25kg for later use;

[0021] 3. Take 5kg of PEG-400 and 80kg of GTCC, put it into the emulsification pot and stir to make it evenly mixed.

[0022] 4. Take 0.25kg of silicon dioxide and 5kg of amoxicillin into the emulsification pot and stir, then use GTCC to set the volume to 100L.

[0023] 5. Turn on the backflow and high-speed shearing device, control the liquid...

Embodiment 2

[0025] Example 2, Amoxicillin, colistin sulfate, ceftiofur, ceftiofur hydrochloride, ceftiofur sodium, tylosin tartrate, tyvanectin tartrate, tilmicosin, tilmicosin phosphate raw materials 5kg (the raw materials are calculated as dry products, and the raw salt is calculated as dry products and raw materials); silicon dioxide 0.25kg; some soybean oil.

[0026] Concrete preparation steps:

[0027] 1. Superfine pulverize the above raw materials so that the particle size is lower than 15um and take 5kg each for later use;

[0028] 2. Take 80kg of soybean oil and put it into the emulsification pot.

[0029] 3. Take 5kg of amoxicillin, put it into the emulsification pot and stir, then use soybean oil to make the volume to 100L.

[0030] 4. Turn on the backflow and high-speed shearing device, control the liquid temperature below 40 degrees, and shear for 20 minutes.

[0031] Repeat the above operations to obtain amoxicillin, colistin sulfate, ceftiofur, ceftiofur hydrochloride, ce...

Embodiment 3

[0032] Example 3, Amoxicillin, colistin sulfate, ceftiofur, ceftiofur hydrochloride, ceftiofur sodium, tylosin tartrate, tyvanectin tartrate, tilmicosin, tilmicosin phosphate raw materials 5kg (the raw materials are calculated as dry products, and the raw salt is calculated as dry products and raw materials); silicon dioxide 0.25kg; some white oil.

[0033] Concrete preparation steps:

[0034] 1. Superfine pulverize the above raw materials so that the particle size is lower than 15um and take 5kg each for later use;

[0035] 2. Take 80kg of white oil and put it into the emulsification pot.

[0036] 3. Take 5kg of amoxicillin, put it into the emulsification pot and stir it, then use white oil to make the volume to 100L.

[0037] 4. Turn on the backflow and high-speed shearing device, control the liquid temperature below 40 degrees, and shear for 20 minutes.

[0038] Repeat the above operations to obtain amoxicillin, colistin sulfate, ceftiofur, ceftiofur hydrochloride, cefti...

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PUM

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Abstract

The invention provides a preparation method of mixed suspension injection liquid for veterinary use. The mixed suspension injection liquid for veterinary use is prepared from 1-10% of drugs,0.1-0.5% of dispersant,84.5-93.9% of liquid solvent and 5% of protective agent. The injection liquid prepared by means of the method has high stability,the sedimentation volume of a preparation is high,and theadhesion of the drugs does not easily occur. By means of the injection liquid,the use of organic solvents is avoided,and the stress of animals is reduced.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a preparation method of veterinary suspension injection. Background technique [0002] Injection is a common preparation form of veterinary medicine. Injection solvents can be divided into aqueous solvents and non-aqueous solvents. Some drugs that are easily soluble and easy to degrade in aqueous solution are mostly made into freeze-dried powder preparations, and drugs that are not easily soluble in aqueous solution can be prepared into clear preparations using organic solvents such as dimethylformamide and dimethyl sulfoxide, or using Vegetable oils are prepared as suspensions. [0003] The one-time investment of freeze-dried powder equipment is large and the preparation is sensitive to light and heat. Some organic solvents are highly irritating and easily cause animal stress, while the use of vegetable oil is likely to cause drug deposition and is difficult to s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/04A61K47/10A61K31/43A61P31/04
CPCA61K9/0019A61K9/10A61K31/43A61K47/02A61K47/10A61P31/04
Inventor 李阳李新逯荷香
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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