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Slow-release florfenicol suspension injection and preparation process thereof

A suspension injection and slow-release florfenib technology, which is applied in liquid delivery, emulsion delivery, medical preparations of non-active ingredients, etc., to achieve good stability, lower production costs, and good needle penetration

Pending Publication Date: 2021-12-24
杭州艾贝德生命科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of Florfenicol mainly include injection, premix, powder liposome, β-cyclodextrin inclusion complex, etc. There are only sporadic reports about its suspension injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for sustained-release florfenicol suspension injection, the steps are as follows:

[0027] 1) First put ethyl oleate into a round bottom flask, fill the bottle mouth with nitrogen gas, and heat at 150 degrees Celsius for 2 hours;

[0028] 2) After cooling to 70 degrees Celsius or below, add antioxidants, wetting agents, and surfactants;

[0029] 3) When each material is added, add it while stirring; add florfenicol after stirring evenly; finally stir together at high speed for 30 minutes;

[0030] 4) Add all the dissolved materials into the colloid mill, colloid mill;

[0031] 5) Finally, divide the solution into sterilized and dry glass bottles and seal them.

[0032] The prepared sustained-release florfenicol suspension injection consists of the following components and quantities: 10-30 parts of florfenicol, 60-80 parts of ethyl oleate, 0.1-0.5 parts of surfactant, polyoxyethylene ether (40) 0.5-1.2 parts of hydrogenated castor oil, 0.9-1.5 pa...

Embodiment 2

[0034] A preparation method for sustained-release florfenicol suspension injection, the steps are as follows:

[0035] 1) First put ethyl oleate into a round bottom flask, fill the bottle mouth with nitrogen gas, and heat at 150 degrees Celsius for 2 hours;

[0036] 2) After cooling to 70 degrees Celsius, add antioxidants, wetting agents, and surfactants;

[0037] 3) When each material is added, add it while stirring; add florfenicol after stirring evenly; finally stir together at high speed for 30 minutes;

[0038] 4) Add all the dissolved materials into the colloid mill, colloid mill;

[0039] 5) Finally, divide the solution into sterilized and dry glass bottles and seal them.

[0040] The prepared sustained-release florfenicol suspension injection consists of the following components and components: 15-35 parts of florfenicol, 70-90 parts of ethyl oleate, 0.1-0.5 parts of surfactant, polyoxyethylene ether (40) 1.7-2.4 parts of hydrogenated castor oil, 1.2-1.7 parts of Sp...

Embodiment 3

[0042] A preparation method for sustained-release florfenicol suspension injection, the steps are as follows:

[0043] 1) Stir and heat ethyl oleate to 70 degrees Celsius first, then add antioxidant and wetting agent in sequence.

[0044] 2) The antioxidant is added at 70 degrees Celsius, and the wetting agent is added when the liquid returns to room temperature.

[0045] 3) When each material is added, add it while stirring; add florfenicol after stirring evenly; finally stir together at high speed for 30 minutes.

[0046] 4) Put all the dissolved materials into the colloid mill, colloid mill.

[0047] 5) Finally, divide the solution into sterilized and dry glass bottles and seal them.

[0048] The prepared Sustained Release Florfenicol Suspension Injection consists of the following components and quantities: 15-35 parts of Florfenicol, 60-90 parts of ethyl oleate, 0.1-90 parts of polyoxyethylene ether (40) hydrogenated castor oil 0.5 parts, Span 80 0.5-1.5 parts, Tween 80...

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Abstract

The invention discloses a florfenicol suspension injection. The florfenicol suspension injection is prepared from the following components in parts by weight of 10 to 30 parts of florfenicol, 60 to 80 parts of ethyl oleate, 1 to 5 parts of a surfactant, 0.1 to 0.9 part of polyoxyethylene ether (40) hydrogenated castor oil, 0.5 to 1.2 parts of span 80, 0.2 to 0.9 part of Tween 80, 0.1 to 0.3 part of poloxamer and 0.1 to 0.9 part of an antioxidant. The preparation process comprises the following steps of firstly, putting ethyl oleate into a round-bottom flask, and heating at 150 DEG C for 2 hours; cooling to 70 DEG C, and separately adding the antioxidant, the surfactant and a wetting agent while stirring; after uniformly stirring, adding florfenicol; and finally, stirring at a high speed for 30 minutes, adding all the dissolved materials into a colloid mill, carrying out colloid milling, sub-packaging the solution, and sealing to obtain a product which is wide in antibacterial range, high in antibacterial activity, small in administration frequency, small in stress, long in slow release time and low in price.

Description

technical field [0001] The invention relates to a chloramphenicol broad-spectrum antibacterial drug specially used for veterinary medicine, in particular to a sustained-release florfenicol suspension injection and a preparation process thereof. Background technique [0002] Florfenicol is also known as florfenicol, but its antibacterial activity and antibacterial spectrum are significantly better than thiamphenicol and chloramphenicol. It can inhibit the bacterial 70S ribosome and combine with the 50S subunit to destroy peptide acyltransferase, thereby inhibiting the extension of the peptide chain and interfering with protein synthesis. It is an excellent animal-specific broad-spectrum antibiotic with a broad antibacterial spectrum, including various Gram-positive and negative bacteria and mycoplasma. Sensitive bacteria include Haemophilus of cattle and pigs, Shigella dysenteriae, Salmonella, Escherichia coli, pneumococcus, influenza bacillus, streptococcus, Staphylococcus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K9/08A61K31/165A61K47/26A61K47/22A61K47/10A61K47/44A61K47/14A61P31/04
CPCA61K9/10A61K9/08A61K9/0019A61K31/165A61K47/26A61K47/22A61K47/10A61K47/44A61K47/14A61P31/04
Inventor 王宝贵张月思含
Owner 杭州艾贝德生命科技研究院有限公司
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