Long-acting cefquinome sulfate injection and preparation method thereof

A technology of cefquinome sulfate and injection, which is applied in the field of long-acting cefquinome sulfate injection and its preparation, can solve the problems of increasing the breeding cost of farms, difficulty in long-term storage, animal stress response, etc., and achieve good flocculation Effect, increase curative effect and effective action time, effect of stable chemical properties

Inactive Publication Date: 2017-10-20
JIANGXI AOXIN BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main disadvantage of cefquinome sulfate injection on the market is that it is not easy to store for a long time,

Method used

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  • Long-acting cefquinome sulfate injection and preparation method thereof

Examples

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Example Embodiment

[0026] Example 1:

[0027] A long-acting cefquinome sulfate injection, the injection comprising the following components and parts by weight content: 2 parts cefquinome sulfate, 3 parts suspending agent, 0.5 parts stabilizer, 0.4 parts antioxidant, polylactic acid-hydroxyl 0.2 parts of acetic acid copolymer, 0.7 parts of crosslinking agent, 1 part of pH stabilizer and 120 parts of dispersion medium.

[0028] Among them, the suspending agent is a mixture of hydrogenated castor oil and ethyl cellulose, and in the suspending agent, the mass ratio of hydrogenated castor oil to ethyl cellulose is 1:1.3; the stabilizer is lecithin; the antioxidant includes butyl Hydroxyanisole and dibutylhydroxytoluene; the crosslinking agent is a mixture of glutaraldehyde and chondroitin oxidized sulfate, and in the crosslinking agent, the mass ratio of glutaraldehyde to chondroitin oxidized sulfate is 1:1.4; pH stabilizer The preparation method is as follows: dissolve hexamethylenetetramine in water, ...

Example Embodiment

[0032] Example 2:

[0033] A long-acting cefquinome sulfate injection, the injection comprising the following components and parts by weight: 3 parts cefquinome sulfate, 2 parts suspending agent, 1 part stabilizer, 0.2 part antioxidant, polylactic acid-hydroxyl 0.4 parts of acetic acid copolymer, 0.3 parts of crosslinking agent, 1.5 parts of pH stabilizer, and 80 parts of dispersion medium.

[0034] Among them, the suspending agent is a mixture of hydrogenated castor oil and ethyl cellulose, and in the suspending agent, the mass ratio of hydrogenated castor oil to ethyl cellulose is 1:0.9; the stabilizer is lecithin; the antioxidant includes dibutyl Hydroxytoluene and propyl gallate; the cross-linking agent is a mixture of glutaraldehyde and oxidized chondroitin sulfate, and in the cross-linking agent, the mass ratio of glutaraldehyde to oxidized chondroitin sulfate is 1:1.2; pH stabilizer The preparation method is as follows: dissolve hexamethylenetetramine in water, then add con...

Example Embodiment

[0038] Example 3:

[0039] A long-acting cefquinome sulfate injection, the injection comprising the following components and parts by weight content: the injection comprising the following components and parts by weight content: 2.2 parts of cefquinome sulfate, 2.8 parts of suspending agent, stabilizer 0.6 part, 0.35 part of antioxidant, 0.25 part of polylactic acid-glycolic acid copolymer, 0.6 part of crosslinking agent, 1.1 part of pH stabilizer, and 110 parts of dispersion medium.

[0040] Among them, the suspending agent is a mixture of hydrogenated castor oil and ethyl cellulose, and in the suspending agent, the mass ratio of hydrogenated castor oil to ethyl cellulose is 1:1; the stabilizer is lecithin; the antioxidant includes dibutyl Hydroxytoluene, propyl gallate and tert-butyl hydroquinone; the cross-linking agent is a mixture of glutaraldehyde and chondroitin oxysulfate, and in the cross-linking agent, the mass ratio of glutaraldehyde to chondroitin oxysulfate is 1:1.5; ...

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Abstract

The invention relates to a long-acting cefquinome sulfate injection and a preparation method thereof. The injection solution comprises, by weight, 2 to 3 parts of cefquinome sulfate, 2 to 3 parts of a suspending aid, 0. 5 to 1 part of a stabilizer, 0.2 to 0.4 parts of an antioxidant, 0.2 to 0.4 parts of a polylactic acid-glycolic acid copolymer, 0.3 to 0.7 parts of a crosslinking agent, 1 to 1.5 parts of a pH stabilizer and 80 to 120 parts of a dispersion medium. In preparation, the suspending aid, stabilizer, antioxidant, polylactic acid-glycolic acid copolymer, crosslinking agent and pH stabilizer are added into the dispersion medium, the mixture is cooled, then cefquinome sulfate is added into the cooled mixture and the mixture is ground. Compared with the prior art, the preparation method improves injection stability and dispersibility and prolongs pharmacodynamic metabolism time. The injection can be slowly released after intramuscular injection, realize a stable drug concentration in the blood, realize the effects the same to those of the multiple interval injection processes of the same type of the conventional dosage form only through one injection process, reduce drug use frequency, reduce a drug use cost and a labor cost and prevent stress response and can be easily stored.

Description

technical field [0001] The invention belongs to the technical field of animal medicine, and relates to a long-acting cefquinome sulfate injection and a preparation method thereof. Background technique [0002] In the process of animal breeding, various antibiotics are often required for rapid treatment of diseased animals. Cefquinoxime sulfate is a broad-spectrum and highly effective cephalosporin antibiotic, which has a wider antibacterial spectrum and stronger bactericidal effect than previous cephalosporins. Its intrinsic antibacterial activity is strong, the dosage is less, and it is stable to penicillinase and β-lactamase. Antibacterial tests in vitro showed that cefquinome sulfate can inhibit common Gram-positive and negative bacteria, including Escherichia coli, Citrobacter, Klebsiella, Pasteurella, Proteus, Salmonella, Myxobacterium Serratia, Haemophilus bovis, Actinomyces pyogenes, Bacillus, Corynebacterium, Staphylococcus aureus, Streptococcus, Bacteroides, Clost...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/14A61K47/44A61K47/38A61K47/34A61P31/04
CPCA61K9/0002A61K9/0019A61K9/10A61K31/546A61K47/14A61K47/34A61K47/38A61K47/44
Inventor 胡鹏飞戴多亮黄静吴有林梁世仁周盛昌王丽娜
Owner JIANGXI AOXIN BIOTECH CO LTD
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